Our laboratory studies the structure and function of
and chromatin in metazoans. The Myb protein family provides us
with a useful
window for exploring chromosome and chromatin biology.
Proteins that contain Myb
domains regulate gene expression, epigenetic
nucleosome assembly and remodeling, histone modification,
telomere maintenance, and
Left: Wen H, Andrejka
L, Ashton J, Karess R, and Lipsick JS.
Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF
via the Myb-MuvB/dREAM complex.
Genes & Development 22: 601-14. (2008)
Sim CK, Perry S, Tharadra SK, Lipsick JS, and Ray A. 2012.
Epigenetic regulation of
olfactory receptor gene expression by the Myb–MuvB/dREAM complex.
Genes & Development 26: