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Our laboratory studies the structure and function of
chromosomes
and chromatin in metazoans. The Myb protein family provides us
with a useful
window for exploring chromosome and chromatin biology.
Proteins that contain Myb
domains regulate gene expression, epigenetic
inheritance,
nucleosome assembly and remodeling, histone modification,
telomere maintenance, and
centromere identity.
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Left: Wen H, Andrejka
L, Ashton J, Karess R, and Lipsick JS.
Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF
via the Myb-MuvB/dREAM complex.
Genes & Development 22: 601-14. (2008)
Right:
Sim CK, Perry S, Tharadra SK, Lipsick JS, and Ray A. 2012.
Epigenetic regulation of
olfactory receptor gene expression by the Myb–MuvB/dREAM complex.
Genes & Development 26:
2483-98. (2012) |