Tetrabenazine (TBZ)
Part 3

What are the possible side effects of TBZ?

Because TBZ depletes neurotransmitters other than dopamine in the brain, it can produce some side effects. By decreasing the amount of serotonin in the brain, TBZ may increase the risk of clinical depression. Also, as a dopamine-depleting drug, TBZ can sometimes lead to Parkinsonian motor symptoms. Parkinson’s disease is the result of too little dopamine in the brain, and is characterized by rigidity and difficulty initiating movement. It is very unlikely, though, that people with HD would get Parkinsonian side effects from using TBZ, as their dopamine levels are so high. (For more information on the relationship between HD and Parkinson’s disease, click here.) Among people with HD who experience side effects with TBZ, most report mild symptoms such as drowsiness, constipation, insomnia (already a common occurrence in HD), akathisia, drooling, weakness, and depression.

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Last Modified: 1-25-06

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