Cells of all kinds are often exposed to sudden changes in their environment that cause stress. They often respond to stress by making different sets of proteins that protect the cell and return it to a healthy balanced state called homeostasis. These stress responses work together to make sure that cells and tissues are protected from the many challenges they encounter. In this chapter, we will look at the heat-shock response, which is a specific response to stress involved in HD and other diseases associated with misfolded proteins.
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