Research in Progress

HD and Lifestyle

Running for Your Life

Researchers have shown that exercise greatly improves health in people with HD. Regular exercise can increase the level of chemicals in the brain called growth factors, or neurotrophic factors, that promote the growth of neurons, especially brain-derived neurotrophic factor (BDNF). BDNF is found in the hippocampus, the part of the brain that regulates memory, emotion, and thought.

Mice that voluntarily ran on a wheel for several days showed higher levels of BDNF in the hippocampus than their more sedentary counterparts. It seems that exercise maintains brain function and plasticity, making the brain more resistant to the damage caused by HD. Neuroplasticity, or plasticity, is the ability of the brain to reorganize pathways between neurons as a result of new experiences. As we acquire knowledge throughout our lives, our brain changes to accommodate new learning. For more information on neuroplasticity, click here.

Since environment influences neuroplasticity, getting enough exercise is important throughout life, especially beyond middle age. Incorporating exercise into your daily routine will help maintain neuroplasticity over time. With increased neuroplasticity comes an increase in the survival of neurons, and thus, a resistance to brain deterioration. Maintaining an adequate plasticity also enhances learning and prevents a decrease in awareness, perception, and memory with age. Experts recommend getting a minimum of 30 minutes of moderate-intensity exercise at least five days a week or 20 minutes of vigorous exercise three days a week.

To find out more about how exercise can help maintain your brain plasticity, please click here.

Last Modified: 5-10-04

An educational product of HOPES, not to be used in place of medical care. For more information about HOPES, click on the Logo. To contact HOPES with comments or questions, click here.