Research in Progress

Selected Huntington’s Disease Research Updates

The Research in Progress section contains selected Huntington’s disease research updates obtained from abstracts and medical publications, including the National Library of Medicine’s search service, PubMed. This chapter, which tracks developments in HD prevention and treatment, will be updated frequently. We thank Huntington’s Disease Lighthouse and HD Blog for inspiring this section and Dr. Graham Dark’s On-Line Medical Dictionary for providing a reference for defining medical terms. However, the information presented below is the full responsibility of the HOPES project. We hope you will check back often for updates!

Please note: These updates are included for their informational value, and are not intended as tips or recommendations.

Cholesterol and HD: an investigation into how HD affects cholesterol homeostasis

1. Gene Therapy
1. “Fast and Cheap”: siRNA in Gene Silencing
2. RNAi: Recognizing the HD Allele
3. Gene Therapy Successful in HD Rats
2. HD and Lifestyle
1. Environmental Enrichment Slows Progress of Disease in HD Mice
2. A Cup of Blueberries a Day Keeps the Doctor Away
3. Catch o’ the Day
4. Running for Your Life
5. Vitamin C Wards Off Colds . . . and HD?
3. Drug Development
1. Lithium Treatment Protects Nerve Cells in HD Rats
2. Paxil: For Depression... and HD?
3. Ever Wonder Why Drugs Fail?
4. Rapamycin: A New Miracle Drug?
5. Laser Sheds Light on Mitochondrial Response to Calcium Ions
6. Hope in a Vial: Possible HD Vaccine
4. Gene Regulation
1. MicroRNAs and Gene Regulation
2. Stimulating NeuroD: Turning on a Transcription Factor for Nerve Cell Maintenance
3. Nuclear Shuttle Proteins and Gene Regulation
4. Blocking SUMO-1: The End of Early Cell Death?
5. GRIK2: The Function of a Modifier Gene in HD
6. Huntingtin on the Job
7. Over-activation of p53 Causes Neurodegeneration
5. Stem Cell Research News
1. From Bone Marrow to Brain
6. Cognitive, Emotional, and Rehabilitative Aspects of HD
1. Changes in Sexual Behavior Accompanying HD
2. Abnormal Behavior Develops Early in HD Mice
3. Negative Consequences of Predictive Testing for HD
4. Texture Modified Diets
7. HD and Other Neurodegenerative Disorders
1. Neurogenesis in Alzheimer’s Disease: Implications for HD?
2. Prion-Related Neurodegenerative Disease
3. Drills and Viruses: Combating Parkinson’s disease
8. Miscellaneous
1. Kenyon’s Worms: Treating HD and Slowing Down Aging
2. Osteoporosis: A Risk for HD Women in Long-Term Care Facilities
3. Meiotic Expansion Mutations
9. Community News Briefs
1. A Case of Genetic Discrimination?
2. HD on TV
3. HD Blog: Discussing the Case of Carol Carr
4. Carol Carr Granted Parole
5. New Internet HD Database to be Launched

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T. Altman, 12/31/04

Last Modified: 10/08/2007

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