Protein aggregation

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Posted by jchoi on Apr 4, 2012 in Drugs and Supplements, Protein aggregation

Gene Silencing

Huntington’s disease (HD) is a genetic disease due to the abnormal CAG expansion of the mutated huntingtin gene. The mutated gene instructs cells in the body to...

Posted by Stephanie Liou on Jun 26, 2011 in Protein aggregation

About Protein Aggregation

The altered huntingtin protein responsible for HD has been shown to contain many more molecules of the amino acid glutamine than regular huntingtin. This abundance of...

Posted by Stephanie Liou on Jun 29, 2010 in Protein aggregation

Antisense Gene Therapy

Antisense gene therapy is a gene silencing technique similar to RNA interference, but uses a slightly different mechanism. The therapy is called a gene silencing...

Posted by Stephanie Liou on Jun 29, 2010 in Protein aggregation

Rapamycin

basic Drug summary: Rapamycin, also known as sirolimus, is an FDA-approved antibiotic and immunosuppressant. It is already being used in organ transplant patients and...

Posted by Stephanie Liou on Jun 29, 2010 in Protein aggregation

Cystamine

range Drug summary: Cystamine is a drug that is thought to inhibit transglutaminase (TGase), an enzyme involved in the formation of huntingtin protein aggregates....

Posted by Stephanie Liou on Jun 29, 2010 in Protein aggregation

Trehalose

medium This chapter discusses a small molecule called trehalose that may help prevent protein aggregation. Everyone has a certain copy, or allele, of the Huntington...

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Gene Silencing

About Protein Aggregation

Antisense Gene Therapy

Rapamycin

Cystamine

Trehalose

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