Causes of Huntington's Disease

Welcome to the Causes of HD. This section discusses some of the mechanisms that are thought to lead up to the observed symptoms of Huntington's disease. It is important to understand that none of the biological mechanisms discussed in the chapters here are single-handedly responsible for "causing" HD. Rather, they are all components of a larger interplay of biological effects that can lead to HD in certain individuals. The first two chapters in particular are especially good starting points for readers who are looking for a solid foundational understanding of Huntington's disease.

Chapters:

• The Inheritance of Huntington's Disease
• The Neurobiology of Huntington's Disease
• Huntingtin Protein and Protein Aggregation
• All About Mutations
• Population Genetics

For users who wish to print out chapters or even entire sections in full, HOPES also offers our chapters in Adobe Reader (pdf) and Microsoft Word (doc) formats. Click here to view and/or download these files.

Last Modified: 7-29-04

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