Kelly Huggins |
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email: khuggins AT
stanford DOT edu
Dept: Materials Science
& Engineering
B.A.
Biochemistry,
Mount Holyoke College
Ph.D.
Chemistry,
University of Washington
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Biotemplating is an inorganic synthetic strategy that exploits
the uniform, regular stable structures of natural biological scaffolds
for nanoparticle formation. Protein assemblies, in particular, exhibit
useful characteristics for biotemplating due to the infinite structures
of different sizes and shapes that form under mild conditions in vitro. In addition, protein
assemblies contain a multitude of exposed sites that can be modified to
interact with the inorganic material of interest. My current project
uses a unique strategy for nanoparticle formation using a
self-assembling protein, clathrin, a key protein in the formation of
coated vesicles that transport cargo across lipid membranes. Clathrin
assembles into cage-like structures in
vivo and can be induced to self-assemble in vitro into 3D cages, cubes,
tetrahedra, and 2D lattice structures, offering a variable surface size
and shape for inorganic nanoparticle formation. With such a flexible
protein biotmeplate, synthesis of 2D and 3D conducting metal/metal
oxide nanostructures (applicable in fuel cells, solar cells, and other
devices) can be carried out under less harsh conditions relative to
traditional synthetic routes, contributing to "greener" strategies in
developing inorganic nanomaterials.
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