LAB

Tiffany Hung, Olivier Binda, Karen S. Champagne, Alex J. Kuo, Kyle Johnson, Howard Y. Chang, Matthew D. Simon, Tatiana G. Kutateladze and Or Gozani (2009). ING4 mediates crosstalk between histone H3K4 trimethylation and H3 acetylation to attenuate cellular transformation. Molecular Cell, 33(2): 248-256.

Nehmé Saksouk, Nikita Avvakumov ,Karen S. Champagne, Tiffany Hung, Yannick Doyon, Christelle Cayrou, Eric Paquet, Mukta Ullah, Anne-Julie Landry, Valérie Côté, Xiang-Jiao Yang, Or Gozani, Tatiana G. Kutateladze and Jacques Côté. (2009) HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail. Molecular Cell, 33(2): 257-265.

McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, and Chua KF (2009). SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair. Aging 1: 109-121.

Pedro V. Peña, Catherine A. Musselman, Alex J. Kuo, William P. Schiemann, Or Gozani, and Tatiana G. Kutateladze (2008). NMR assignments and histone specificity of the ING2 PHD. Magnetic Resonance in Chemistry, in press.

Kachirskaia I, Shi X, Yamaguchi H, Tanoue K, Wen H, Wang EW, Appella E, and O. Gozani (2008). Role for 53BP1 tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. Journal of Biological Chemistry, 283(50):34660-6.

Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, and D. Mathis (2008). Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci, 105(41): 15878-83.

P. V. Peña, R. A. Hom, T. Hung, H. Lin, A. J. Kuo, R. P. C. Wong, O. M. Subach, K. S. Champagne, R. Zhao, V. V. Verkhusha, G. Li, O. Gozani and T. G. Kutateladze (2008). Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor. J. Mol. Biol. 380, 303-312.

Michishita, E., McCord, R.A., Berber E., Kioi, M., Padilla-Nash, H,, Damian, M., Cheung, P., Kusomoto, R., Kawahara, T.L.A., Barrett, J.C., Chang, H.Y., Bohr, V.A., Ried, T., Gozani, O. and K.F. Chua (2008). SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature, 452, 492-496.

Adam G. W. Matthews*, Alex J. Kuo*, Santiago Ramon-Maiques, Sunmi Han, Karen S. Champagne, Dmitri Ivanov, Mercedes Gallardo, Dylan Carney, Peggie Cheung, David N. Ciccone, Kay L. Walter, Paul J. Utz, Yang Shi, Tatiana G. Kutateladze, Wei Yang, Or Gozani# & Marjorie A. Oettinger# (2007). RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature, 450(7172):1106-10.
*These authors contributed equally to this work
#Equal correspondence

Santiago Ramon-Maiques, Alex J. Kuo, Dylan Carney, Adam G. W. Matthews, Marjorie A. Oettinger, Or Gozani, and Wei Yang (2007). The PHD finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. PNAS, 104(48):18993-8.

Shi, X., Kachirskaia, I., Yamaguchi, H., West, L.E., Wen, H., Wang, E.W., Dutta, S., Appella, E. and O. Gozani (2007). Modulation of p53 function by SET8-mediated methylation at lysine 382. Molecular Cell, 27: 636-646.

Lan, F., Collins, R.E., Cegli, R., Alpatov, R., Horton, J.R., Shi, X., Gozani. O, Cheng, X. and Y. Shi (2007). Recognition of un-methylated H3K4 by the BHC80 PHD finger links BHC80 to LSD1 mediated gene repression. Nature,448, 718-722.

Huang, W., Zhang, H., Davrazou, F., Kutateladze, T.G., Shi, X., Gozani, O. and G.D. Prestwich (2007). Stabilized Phosphatidylinositol-5-Phosphate Analogues as Ligands for the Nuclear Protein ING2: Chemistry, Biology and Molecular Modeling. J Am Chem Soc. 2007 May 23;129(20):6498-506.

Shi, X., Kachirskaia, I., Walter K.L., Kuo, J.H., Lake A., Davrazou, F., Chan, S.M., Martin, D.G., Fingerman, I.M., Briggs, S.D., Howe, L., Utz, P.J., Kutateladze, T.G., Lugovskoy, A.A., Bedford, M.T., and O. Gozani (2007). Proteome-wide analysis in S. cerevisae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. Journal of Biological Chemistry, 282, 2450-2455.

David G. E. Martin, Kristin Baetz, Xiaobing Shi, Kay L. Walter, Vicki E. MacDonald, Martin J. Wlodarski, Or Gozani, Philip Hieter, and LeAnn Howe (2006). The Yng1p Plant Homeodomain Finger Is a Methyl-Histone Binding Module That Recognizes Lysine 4-Methylated Histone H3. Molecular and Cellular Biology, 26: 7871-7879. [Full Text PDF]

Xiaobing Shi, Tao Hong, Kay L. Walter, Mark Ewalt, Eriko Michishita, Tiffany Hung, Dylan Carney, Pedro Pea, Fei Lan, Mohan R. Kaadige, Nicolas Lacoste, Christelle Cayrou, Foteini Davrazou, Anjanabha Saha, Bradley R. Cairns, Donald E. Ayer, Tatiana G. Kutateladze, Yang Shi, Jacques Ct, Katrin F. Chua,  and Or Gozani (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.  Nature, 442, 96 - 99. [Full Text PDF]

Pedro V. Peña, Foteini Davrazou, Xiaobing Shi, Kay L. Walter, Vladislav V. Verkhusha, Or Gozani, Rui Zhao and Tatiana G. Kutateladze (2006). Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.  Nature, 442, 100 - 103. [Full Text PDF]

Caroline Pendaries, Hélène Tronchère, Laurence Arbibe, Joelle Mounier, Or Gozani, Lewis Cantley, Michael J Fry, Frédérique Gaits-Iacovoni, Philippe J Sansonetti and Bernard Payrastre (2006). PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. The EMBO Journal, 25: 1024–1034. [Full Text PDF]

Sheryl K. Elkin, Dmitri Ivanov, Mark Ewalt, Colin G. Ferguson, Sven G. Hyberts, Zhen-Yu J. Sun, Glenn D. Prestwich, Junying Yuan, Gerhard Wagner, Marjorie A. Oettinger, Or Gozani (2005). A PHD finger motif in the C-terminus of RAG2 modulates recombination activity. Journal of Biological Chemistry, 280(31): 28701-10. [Full Text PDF]

Or Gozani, Seth J. Field, Colin G. Ferguson, Mark Ewalt, Christopher Mahlke, Lewis C. Cantley, Glenn D. Prestwich, Junying Yuan (2005). Modification of protein sub-nuclear localization by synthetic phosphoinositides: Evidence for nuclear phosphoinositide signaling mechanisms. Advances in Enzyme Regulation, 45: 171-85. [Full Text PDF]

Xiaobing Shi and Or Gozani (2005). The Fellowships of the INGs. Journal of Cellular Biochemistry, 96(6): 1127-1136. [Full Text PDF]

Or Gozani*, Philip Karuman*, David R. Jones, Dmitri Ivanov, James Cha, Alexey A. Lugovskoy, Cheryl L. Baird, Hong Zhu, Seth J. Field, Stephen L. Lessnick, Jennifer Villasenor,  Bharat Mehrotra, Jian Chen, Vikram R. Rao, Joan S. Brugge, Colin G. Ferguson, Bernard Payrasre, David G. Myska, Lewis C. Cantley, Gerhard Wagner, Nullin Divecha, Glenn D. Prestwich, and Junying Yuan (2003). The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.  Cell, 114: 99-111. [Full Text PDF]
* These authors contributed equally to this work

Or Gozani, Michael Boyce, Lina Yoo, Philip Karuman and Junying Yuan (2002). Life and Death in Paradise. Nature Cell Biology, 4:E159-E162.C. [Full Text PDF]