PUBLICATIONS

James E. Ferrell Jr.

 

For lab members' papers other than Jim Ferrell's, click here:

Ubersax JA, Ferrell JE Jr. (2006) A noisy 'Start' to the cell cycle. Mol Syst Biol 2:2006.0014.

Yue J, Xiong W, Ferrell JE (2006) B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts. Oncogene 25: 3307-3315.

Yue J, Ferrell JE Jr. (2006) Mechanistic studies of the mitotic activation of Mos. Mol Cell Biol 26: 5300-5309.

Myers JW, Chi JT, Gong D, Schaner ME, Brown PO, Ferrell JE Jr. (2006) Minimizing off-target effects by usiing diced siRNAs for RNA interference. J RNAi Gene Silencing in press.

Pomerening JR, Kim SY, Ferrell JE Jr. (2005) Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell 122: 565-578.

Myers JW, Ferrell JE Jr. (2005) Silencing gene expression with Dicer-generated siRNA pools. In: Carmichael GG, editor. RNA Silencing:  Methods and Protocols. Totowa NJ: Humana Press Inc. pp. 93-196.

Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr., Meyer T (2005) STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol 15: 1235-1241.

Kim SY, Song EJ, Lee KJ, Ferrell JE Jr. (2005) Multisite M-phase phosphorylation of Xenopus Wee1A. Mol Cell Biol 25: 10580-10590.

Green SL, Westendorf JM, Jaffe H, Pant HC, Cork LC, Ostrander EA, Vignaux F, Ferrell JE Jr. (2005) Allelic variants of the canine heavy neurofilament (NFH) subunit and extensive phosphorylation in dogs with motor neuron disease. J Comp Pathol 132: 33-50.

Brandman O, Ferrell JE Jr., Li R, Meyer T (2005) Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310: 496-498.

Yue J, Ferrell JE Jr. (2004) Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts. Curr Biol 14: 1581-1586.

Jones JT, Myers JW, Ferrell JE, Meyer T (2004) Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol 22: 306-312.

Angeli D, Ferrell JE Jr., Sontag E (2004) Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc Natl Acad Sci USA 101: 1822-1827.

Xiong W, Ferrell JE Jr. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature. 2003 Nov 27;426(6965):460-5. PubMed | PDF

Fink CC, Bayer KU, Myers JW, Ferrell JE Jr, Schulman H, Meyer T. Selective regulation of neurite extension and synapse formation by the besta but not the alpha isoform of CaMKII. Neuron. 2003 Jul 17;39(2):283-97. PubMed |

Pomerening JR, Sontag ED, Ferrell JE Jr . Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol. 2003 Mar 10. PubMed | PDF

Myers JW, Jones JT, Meyer T, Ferrell JE Jr . Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol. 2003 Mar;21(3):324-8. PubMed | PDF

Ferrell JE Jr , Cimprich KA. Enforced proximity in the function of a famous scaffold. Mol Cell. 2003 Feb;11(2):289-91. PubMed | PDF

Bagowski CP, Besser J, Frey CR, Ferrell JE Jr. The JNK Cascade as a Biochemical Switch in Mammalian Cells. Ultrasensitive and All-or-None Responses. Curr Biol. 2003 Feb 18;13(4):315-20. PubMed | PDF

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12;420(6916):703-6. PubMed | PDF

Ferrell JE Jr. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol. 2002 Apr;14(2):140-8. Review. PubMed |PDF

Sohaskey ML, Ferrell JE Jr. Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes. Mol Biol Cell. 2002 Feb;13(2):454-68. PubMed | PDF

Deshaies RJ, Ferrell JE Jr. Multisite phosphorylation and the countdown to S phase. Cell. 2001 Dec 28;107(7):819-22. Review. PubMed | PDF

Ferrell JE Jr. Six steps to destruction. Nature. 2001 Nov 29;414(6863):498-9. PubMed | PDF

Bagowski CP, Myers JW, Ferrell JE Jr. The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes. J Biol Chem. 2001 Oct 5;276(40):37708-14. PubMed | PDF

Bagowski CP, Ferrell JE Jr. Bistability in the JNK cascade. Curr Biol. 2001 Aug 7;11(15):1176-82. PubMed | PDF

Ferrell JE Jr, Xiong W. Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible. Chaos. 2001 Mar;11(1):227-236. PubMed |

Bagowski CP, Xiong W, Ferrell JE Jr. c-Jun N-terminal kinase activation in Xenopus laevis eggs and embryos. A possible non-genomic role for the JNK signaling pathway. J Biol Chem. 2001 Jan 12;276(2):1459-65. PubMed | PDF

Green SL, Lifland BD, Bouley DM, Brown BA, Wallace RJ Jr, Ferrell JE Jr. Disease attributed to Mycobacterium chelonae in South African clawed frogs (Xenopus laevis). Comp Med. 2000 Dec;50(6):675-9. PubMed | PDF

Ferrell JE Jr. What do scaffold proteins really do? Sci STKE. 2000 Oct 3;2000(52):PE1. Review. PubMed|PDF

Bhatt RR, Ferrell JE Jr. Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs. J Biol Chem. 2000 Oct 20;275(42):32983-90. PubMed | PDF

Kim SY, Ferrell JE Jr, Chae SK, Lee KJ. Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23. Cell Growth Differ. 2000 Sep;11(9):485-90. PubMed | PDF

Walter SA, Guadagno SN, Ferrell JE Jr. Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts. Mol Biol Cell. 2000 Mar;11(3):887-96. PubMed | PDF

Sohaskey ML, Ferrell JE Jr. Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo. Mol Biol Cell. 1999 Nov;10(11):3729-43. PubMed | PDF

Bhatt RR, Ferrell JE Jr. The protein kinase p90 rsk as an essential mediator of cytostatic factor activity. Science. 1999 Nov 12;286(5443):1362-5. PubMed | PDF

Ferrell JE Jr. Building a cellular switch: more lessons from a good egg. Bioessays. 1999 Oct;21(10):866-70. Review. PubMed | PDF

Ferrell JE Jr. Xenopus oocyte maturation: new lessons from a good egg. Bioessays. 1999 Oct;21(10):833-42. Review. PubMed | PDF

Green SL, Bouley DM, Tolwani RJ, Waggie KS, Lifland BD, Otto GM, Ferrell JE Jr. Identification and management of an outbreak of Flavobacterium meningosepticum infection in a colony of South African clawed frogs (Xenopus laevis). J Am Vet Med Assoc. 1999 Jun 15;214(12):1833-8, 1792-3. PubMed | PDF

Huang CY, Chang CP, Huang CL, Ferrell JE Jr. M phase phosphorylation of cytoplasmic dynein intermediate chain and p150(Glued). J Biol Chem. 1999 May 14;274(20):14262-9. PubMed | PDF

Ferrell JE Jr. How regulated protein translocation can produce switch-like responses. Trends Biochem Sci. 1998 Dec;23(12):461-5. Review. PubMed | PDF

Guadagno TM, Ferrell JE Jr. Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts. Science. 1998 Nov 13;282(5392):1312-5. PubMed | PDF

Ferrell JE Jr, Machleder EM. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science. 1998 May 8;280(5365):895-8. PubMed | PDF

Walter SA, Guadagno TM, Ferrell JE Jr. Induction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinase. Mol Biol Cell. 1997 Nov;8(11):2157-69. PubMed | PDF

Ferrell JE Jr. How responses get more switch-like as you move down a protein kinase cascade. Trends Biochem Sci. 1997 Aug;22(8):288-9. PubMed | PDF

Ferrell JE Jr, Bhatt RR. Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase.
J Biol Chem. 1997 Jul 25;272(30):19008-16. PubMed | PDF

Wang XM, Zhai Y, Ferrell JE Jr. A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells. J Cell Biol. 1997 Apr 21;137(2):433-43. PubMed | PDF

Ferrell JE Jr. Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem Sci. 1996 Dec;21(12):460-6. Review. PubMed | PDF

Huang CY, Ferrell JE Jr. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10078-83. PubMed | PDF

Huang CY, Ferrell JE Jr. Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system. EMBO J. 1996 May 1;15(9):2169-73. PubMed | PDF

Ferrell JE Jr. MAP kinases in mitogenesis and development.
Curr Top Dev Biol. 1996;33:1-60. Review. PubMed | PDF

Hsiao KM, Chou SY, Shih SJ, Ferrell JE Jr. Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5480-4. PubMed | PDF

Chou SY, Baichwal V, Ferrell JE Jr. Inhibition of c-Jun DNA binding by mitogen-activated protein kinase. Mol Biol Cell. 1992 Oct;3(10):1117-30. PubMed | PDF