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Lecture/Seminar for graduate students, advanced undergraduates and coterminal master's students. The class will constitute a comprehensive exploration of the biochemistry, genetics and molecular biology of the ubiquitin system and its central role in the biology of the eukaryotic cell. Topics: biochemistry and enzymology of ubiquitin-dependent proteolysis, function of proteolysis in cell cycle control, transcriptional regulation, cellular signalling, vesicular trafficking and quality control of misfolded proteins. The class will also review the role of the ubiquitin system in the pathogenesis of neurodegenerative diseases and cancer. Class will include lectures by the instructors and student presentations. Prerequisite: Biology 41, 42, 118 or equivalent.