Fang Lab Research

Publications

1. Fang, G. and T.R. Cech. 1991. Molecular cloning of telomere-binding protein genes from Stylonychia mytilus. Nucleic Acids Res. 19, 5515-5518.

2. Fang, G. and T.R. Cech. 1993. The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA. Cell 74, 875-885.

3. Fang, G. and T.R. Cech. 1993. Characterization of a G-quartet formation reaction promoted by the beta subunit of Oxytricha telomere-binding protein. Biochemistry 32, 11646-11657.

4. Fang, G., J.T. Gray, and T.R. Cech. 1993. Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha subunit. Genes & Dev. 7, 870-882.

5. Fang, G. and T.R. Cech. 1993. Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits. Proc. Natl. Acad. Sci. USA 90, 6056-6060.

6. Fang, G. and T. R. Cech. 1995. Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. J. Cell Biol. 130, 243-253.

7. Fang, G. and T.R. Cech. 1995. Telomere Proteins. In Cold Spring Harbor Monograph on Telomeres, E.H. Blackburn and C.W. Greider, eds. (Cold Spring Harbor, New York), p. 69-105.

8. Fang, G., H. Yu and M.W. Kirschner. 1998. Direct binding of the CDC20 protein family activates the anaphase-promoting complex in mitosis and G1. Molecular Cell 2, 163-171.

9. Fang, G., H. Yu and M.W. Kirschner. 1998. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & Dev. 12, 1871-1883.

10. Fang, G., H. Yu and M.W. Kirschner. 1999. Mitotic proteolysis. Philosophical Transactions of the Royal Society: Biological Sciences 354, 1583-1590.

11. Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H., Kirschner, M.W., and G. Wagner. 2000. Structure of the MAD2 spindle checkpoint protein and its interactions with CDC20. Nature Structural Biology 7, 224-229.

12. Howell, B., Hoffman, D.B., Fang, G., Murray, A.W., and E.D. Salmon. 2000. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J. Cell Biol. 150, 1233-1250.

13. Chen, J. and G. Fang. 2001. MAD2B is an inhibitor of the anaphase-promoting complex. Genes & Dev 15, 1765-1770.

14. Kang, D., Chen, J., Wong, J. and G. Fang. 2002. The checkpoint protein Chfr is a ubiquitin ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156: 249-259.

15. Fang, G. 2002. The checkpoint protein BubR1 acts synergistically with Mad2 to inhibit the anaphase-promoting complex.  Mol. Biol. Cell 13:755-66.

16. Canman, J.C., Salmon, T., and G. Fang. 2002. Inducing precocious anaphase in cultured mammalian cells. Cell Motility and the Cytoskeleton 52: 61-65.

17. Canman, J.C., Sharma, N., Straight, A., Shannon, K., G. Fang, and Salmon, E.D. 2002. Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins. J Cell Science 115: 3787-3795.

18. Canman, J., Cameron, L., Maddox, P., Tirnauer, J., Straight, A., Mitchison, T., Fang, G., Kapoor, T. and E. Salmon. 2003. Stimulation of cytokinesis by asymmetric monopolar spindles. Nature 424: 1074-8.

19. Gupta, A., Inaba, S., Wong, O.K., Fang, G. and J. Liu. 2003. The breast cancer specific gene 1 interacts with the mitotic checkpoint kinase BubR1. Oncogene 22: 7593-7599.

20. DeLuca, J.G., Howell, J.B., Canman, J.C., Hickey, J. M., G. Fang. and E.D. Salmon. 2003. Nuf2 and Hec1 are required for retention, but not for recruitment, of the checkpoint proteins Mad2 and Mad1 to kinetochores. Current Biology 13: 2103-2109.

21. Kang, D., Wong, J. and G. Fang. 2004. Functional analysis of the Chfr ubiquitin ligase in G2/M checkpoint control. In Methods in Molecular Biology – Checkpoint Control and Cancer, A.H. Schonthal, ed. (Humana Press), p.229-244.

22. Howell, B.J., Moree, B., Farrar, E.M, Stewart, S, G. Fang. and E.D. Salmon. 2004. BubR1, Bub3, Mad2 and Mps1, but not Mad1 or Bub1, are dynamic components of the kinetochore wait anaphase signal that inhibits APC/C in the cytoplasm. Current Biology 14: 953-964.

23. Yu, X., Minter-Dykhouse, K., Malureanu, L., Zhao, W.M., Zhang, D., Merkle, C.J., Ward, I.M., Saya, H., Fang, G., van Deursen. J. and J. Chen. 2005. Chfr is required for tumor suppression and Aurora A regulation. Nature Genetics 37: 401-406.

24. Zhao, W. and G. Fang. 2005. Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. J. Bio. Chem. 280: 33516-33524.

25. Wong, O. and G. Fang. 2005. Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores. J. Cell Biol. 170: 709-719.

26. Stewart, S. and G. Fang. 2005. Destruction box-dependent degradation of Aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1. Cancer Research 65: 8730-8735.

27. Zhao, W. and G. Fang. 2005. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc. Natl. Acad. Sci. USA 102: 13158-13163.

28. Stewart, S. and G. Fang. 2005. Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Mol. Cell. Bio. 25: 10516-10527.

29. Wong, J. and G. Fang. 2006. HURP Controls Spindle Dynamics to Promote Proper Inter-kinetochore Tension and Efficient Kinetochore Capture. J. Cell Biol. 173: 879-891.

30. Zhao, W., Seki, A. and G. Fang. 2006. Cep55, a Microtubule-Bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis. Mol. Biol.Cell 17: 3881-3896.

31. Wong, O. and G. Fang. Loading of the 3F3/2 Antigen onto Kinetochores is Dependent on the Ordered Assembly of the Spindle Checkpoint Proteins. Mol. Biol. Cell in press.

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