Mark M. Davis - CV

Curriculum Vitae

Prof. Mark M. Davis

 

Contact

Name:    Barbara Whyte

Title:      Administrative Assistant

Email:    bwhyte [at] stanford . edu

Phone:    650-725-4755

Web:      http://davislab.stanford.edu

 

 

Academic Appointments

 

Appointment                       Organization

Professor                            Microbiology & Immunology

Member                             Bio-X

Member                             Cancer Center

 

 

Graduate & Fellowship Program Affiliations

 

Biophysics ; Immunology ; Microbiology and Immunology

 

           

Education / Training

 

Johns Hopkins Univ., Baltimore, MD                         B.A.               1974               Molecular Biology

California Inst. of Technology, Pasadena, CA             Ph.D.              1981               Molecular Biology

National Institutes of Health, Bethesda, MD               Postdoc          1980-82         Immunology

 

                                   

Positions and Employment

 

1982-1983       Staff Fellow, Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland

June 1983        Instructor, Molecular Cloning Course, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

1983-Present   Faculty Member of the Department of Microbiology and Immunology

1987-Present   Member of the Howard Hughes Medical Institute, currently Investigator

2002-2004       Chair of the Department of Microbiology and Immunology

2004-Present   Director, Stanford Institute for Immunity, Transplantation and Infection

 


Honors and Awards

 

1981                Milton and Francis Clauser Doctoral Prize, Caltech

1985                Passano Young Scientist Award, Passano Foundation

1985-1989       Scholar of the PEW Foundation

1986                Eli Lilly Award in Microbiology and Immunology

1988                Howard Taylor Ricketts Award, University of Chicago

1988-1992       Member of the Allergy and Immunology Study Section, National Institutes of Health

1989                Gairdner Foundation International Award)

1993                Member, National Academy of Sciences

1995                The King Faisal International Prize in Medicine

1996                Alfred P. Sloan Prize from the General Motors Cancer Research Foundation

1998                Novartis Prize for Basic Immunology

2000                American Academy of Arts and Sciences

2000                William B. Coley Award from the Cancer Research Institute

2000-2001       Newton-Abraham visiting Professorship at the University  of  Oxford

2002-2006       The Burt and Marion Avery Professor of Immunology

2002                The Rose Payne Award, American Society for Histocompatibility and Immunogenetics

2003                The Ernst W. Bertner Memorial Award, The University of Texas M.D. Anderson Cancer Center

2004                Paul Ehrlich / Ludwig Darmstaedter Prize Paul Ehrlich Institute, Germany

Distinguished Alumni Award, California Institute of Technology

                        The Ellison Medical Foundation Senior Scholar in Aging Award

                        The Burt and Marion Avery Family Professor of Immunology

 

 

Selected peer-reviewed publication (Publications selected from 260 peer-reviewed publictions)

 

  1. Davis, M.M. and P.J. Bjorkman.  T cell antigen receptor genes and T cell recognition.  Nature, 334:395-402, 1988.
  2. Matsui, K., J.J. Boniface, P.A. Reay, H. Schild, B. Fazekas de St. Groth, and M.M. Davis.  Low affinity interaction of peptide-MHC complexes with T cell receptors.  Science,  254:1788-1791, 1991.
  3. Altman, J.D., P.A.H. Moss, P. Goulder, D.H. Barouch, M. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis.  Phenotypic analysis of antigen-specific T lymphocytes.  Science, 274:94-96, 1996.
  4. Wülfing, C. and M.M. Davis.  A receptor/cytoskeletal movement triggered by co-stimulation during T cell activation.  Science, 282:2266-2269, 1998.
  5. Krummel, M.F., M. Sjaastad,C. Wülfing, and M.M. Davis. Differential clustering of CD4 and CD3z during T cell recognition. Science, 289:1349-1352, 2000.
  6. Savage, P.A. and M.M. Davis. A kinetic window shapes the T cell receptor repertoire in the thymus.  Immunity, 10:485-492, 2001.
  7. Wülfing, C., C. Sumen, M.D. Sjaastad, L.C. Wu, M.L. Dustin, and M.M. Davis.  Costimulation and endogenous MHC ligands contribute to T cell recognition.  Nature Immunol, 3:42-47, 2002.
  8. Wu, L.C., D. S. Tuot, D.S. Lyons, K.C. Garcia, and M.M. Davis.  Two-step binding mechanism for T-cell receptor recognition of peptide-MHC.  Nature, 418:552-556, 2002.
  9. Irvine, D.J., M.A. Purbhoo, M. Krogsgaard, and M.M. Davis.  Direct observation of ligand recognition by T cells. Nature, 419:845-849, 2002.
  10. Davis, M.M., M. Krogsgaard, J.B. Huppa, C. Sumen, M.A. Purbhoo, D.J. Irvine, L.C. Wu, and L. Ehrlich. Dynamics of cell surface molecules during T cell recognition. Ann Rev Biochem,  72:717-742, 2003.
  11. Huppa, J.B., M. Gleimer, C. Sumen, and M.M. Davis.  Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nature Immunol, 4:749-755, 2003.
  12. Krogsgaard M, N. Prado, E.J. Adams, X.-l. He, D.-C. Chow, D.B. Wilson, K.C. Garcia, and M.M. Davis.
  13. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell
  14. activation.  Mol Cell, 12:1367-1378, 2003.
  15. Huppa, J.B. and M.M. Davis.  T-cell antigen recognition and the immunological synapse. Nature Rev Immunol, 3:973-983, 2003.
  16. Purbhoo, M.C., D.J. Irvine, J.B. Huppa, and M.M. Davis.  T cell killing does not require the formation of a stable mature immunological synapse. Nature Immunol, 5:524-530, 2004.
  17. Sciammas, R. and M.M. Davis. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol, 172:5427-5440, 2004.
  18. Qi-Jing Li, A.R. Dinner, S. Qi, D.J. Irvine, J.B. Huppa, M.M. Davis, and A.K. Chakraborty,  CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse, Nature Immunol, 5:791-799, 2004.
  19. Krogsgaard, M. and M.M. Davis.  How T cells 'see' antigen. Nature Immunol, 6:239-245, 2005.
  20. Krogsgaard, M., Q.-j. Li, C. Sumen, J.B. Huppa, M. Huse, and M.M. Davis.  Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature, 434:238-243, 2005.
  21. Chen, D.S., Y. Soen, T.B. Stuge, P.P. Lee, J.S. Weber, P.O. Brown, and M.M. Davis. Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray.  PloS Med, 2(10):1018-1030, 2005.
  22. Huse, M., B.F. Lillemeier, M.S. Kuhns, D.S. Chen and M.M. Davis. T cells use two directionally distinct pathways for cytokine secretion. Nature Immunol, 7:247-255, 2006.
  23. Qi, S., M. Krogsgaard, M.M. Davis and A.K. Chakraborty. Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions. PNAS, 12:4416-4421, 2006.
  24. Chen, D.S. and M.M. Davis. Molecular and functional analysis using live cell microarrays. Curr Opin In Chem Biol, 10:28-34, 2006.
  25. Kuhns, M.S., M.M. Davis, and K.C. Garcia. Deconstructing the form and function of the TCR/CD3 complex. Immunity, 24:133-139, 2006.
  26. Singleton, K., N. Parvaze, K.R. Dama, K.S. Chen, P. Jennings, B. Purtic, M.D. Sjaastad, C. Gilpin, M.M. Davis, and C. Wulfing. A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse. J. Immunol., 177(7):4402-13, 2006.
  27. Lillemeier, B.F., J.R. Pfeiffer, Z. Surviladze, B.S. Wilson, and M.M. Davis.  Plasma membrane-associated protreins are clustered into ‘islands’ attached to the cytoskeleton. PNAS, 103(50):18992-97, 2006.
  28. Davis, M.M., M. Krogsgaard, M. Huse, J. Huppa, B. Lillemeier, and Q. Li.  T cells as a self-referential, sensory organ. Annu. Rev. Immunol., 25:681-95, 2007.
  29. Kuhns, M.S., and Davis, M.M.  Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling. Immunity, 26:357-369, 2007.
  30. Davis, M.M.  Blimp-1 over Budapest.  Nat. Imm. 8:445-447, 2007.
  31. Li, Q-J, J. Chau, P.J.R. Ebert, G. Sylvester, H. Min, G. Liu, R. Braich, M. Mahoharan, J. Soutchek, P.Skare, L.O. Klein, M.M. Davis, and C-Z. Chen: miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection. Cell, 129:147-161, 2007.
  32. Bankovich, A.J., S. Raunser, Z.S. Juo, T. Walz, M.M. Davis, and K.C. Garcia. Structural Insight into Pre-B Cell Receptor Function. Science. 316:291-294, 2007.
  33. Krogsgaard, M., J. Juang, and Davis, M.M.: A role for “self” in T-cell activation.  Seminars in Immunol, 19(4):236-44, 2007.
  34. Huse, M., L.O. Klein, A.T. Girvin, J.M. Faraj, Q-J Li, M.S. Kuhns, and M.M. Davis.  Spatial and Temporal Dynamics of T Cell Receptor Signaling Using a Photoactivatable Agonist. Immunity, 27:76-88, 2007.
  35. Davis, M.M.:  The ab T Cell Repertoire Comes Into Focus. Immunity Previews, 27:1-2, 2007.
  36. Davis, M.M. and Y. Chien. “T Cell Antigen Receptors.” In Fundamental Immunology.  W.E. Paul (ed.), Lippincott William s & Wilkins Publishers, New York, New York, 6th edition,  Chapter 10, Pp. 313-345, 2008.
  37. Jensen, K.DC., X. Su, S. Shin, L. Li, S. Youssef, S. Yamasaki, L. Steinman, T. Salto, R.M. Locksley, M.M. Davis, N. Baumgarth, Y-h. Chien.  Thymic Selection Determines  T Cell Effector Fate: Antigen-Naïve Cells make Interleukin-17 and Antigen-Experienced Cells Make Interferon. Immunity, 29:1-11, 2008.
  38. Huse, M., E.J. Quann, M.M. Davis. Shouts, Whispers, and the Kiss of Death: Directional Secretion in T Cells. Nat. Immunol., 9(10):839-845, 2008.
  39. Swijnenburg, R-J, S. Schrepfer, J.A. Govaert, F. Cao, K. Ransohoff, A.Y. Sheikh, M. Haddad, A.J. Connolly, M.M. Davis, R.C. Robbins, J.C. Wu. Immunosuppressive Therapy Mitigates Immunological Rejection of Human Embryonic Stem Cell Xenografts. PNAS, 105(35):1299-6, 2008.
  40. Ebert, P.J.R., L.I.R. Ehrlich, and M.M. Davis: Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.  Immunity, 29(5):734-45, 2008.
  41. Kuhns, M.S., and M.M. Davis.  The safety on the TCR trigger. Cell, 135(4):594-6, 2008.
  42. Davis, M.M.  A prescription for human immunology. Immunity, 2008.
  43. Shen-Orr, SS, O. Goldberger, Y. Garten, Y. Rosenberg-Hasson, P.A. Lovelace, D.L. Hirschberg, R.B. Altman, M.M. Davis, A.J. Butte:  Towards a cytokine-cell interaction knowledgebase of the adaptive immune system.  Proceedings Pacific Symposum on Biocomputing 14:439-450, 2009.