DiMartino
JF, Miller T, Ayton PM, Landewe T, Hess JL, Cleary ML, Shilatifard A
A carboxy-terminal domain of ELL is required and sufficient for
immortalization of myeloid progenitors by MLL-ELL.
Blood 96:3887-3893, 2000.
Firestein
R, Cui X, Huie P, Cleary ML
SET domain-dependent regulation of transcriptional silencing and
growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.
Mol Cell Biol 20:4900-4909, 2000.
Jacobs
Y, Schnabel CA, Cleary ML
Trimeric association of Hox and TALE homeodomain proteins mediates
Hoxb2 hindbrain enhancer activity.
Mol Cell Biol 19:5134-5142, 1999.
Piper
D, Bachelor A, Chang C-P, Cleary ML, Wolberger C
Structure of a HoxB1-Pbx1a heterodimer bound to DNA: Role
of the hexapeptide and a fourth homeodomain helix in complex formation.
Cell 96:587-597, 1999.
Chang
C-P, Jacobs Y, Nakamura T, Jenkins NA, Copeland NG, Cleary ML
Meis proteins are major in vivo DNA binding partners for wild type
but not chimeric Pbx proteins.
Mol Cell Biol 17:5679-5687, 1997.
Chang
C-P, Brocchieri L, Shen W-F, Largman C, Cleary ML
Pbx modulation of Hox homeodomain amino-terminal arms establishes
different DNA-binding specificities across the Hox locus.
Mol Cell Biol 16:1734-1745, 1996.
Chang
C-P, Shen W-F, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML
Pbx proteins display hexapeptide-dependent cooperative DNA binding
with a subset of Hox proteins.
Genes & Dev 9:663-674, 1995.
LeBrun
DP, Cleary ML
Fusion with E2A alters the transcriptional properties of the homeodomain
protein PBX1 in t(1;19) leukemias.
Oncogene 9:1641-1647, 1994.
Monica
K, Galili N, Nourse J, Saltman D, Cleary ML
PBX2 and PBX3, new homeobox genes with extensive homology to the
human proto-oncogene PBX1.
Mol Cell Biol 11: 6149-6157, 1991.
Slany
R, Lavau C, Cleary ML
The oncogenic capacity of HRX-ENL requires the transcriptional transactivation
activity of ENL and the DNA binding motifs of HRX.
Mol Cell Biol 18:122-129, 1998.
Waring
PM, Cleary ML
Disruption of a homolog of trithorax by 11q23 translocations:
Leukemogenic and transcriptional implications.
In: Chromosomal Translocations and Oncogenic Transcription Factors.
FJ Rauscher, PK Vogt, eds. (Springer, Berlin).
Curr Topics Micro Immuno 220:1-23, 1997. Review.
No abstract available.
Lavau
C, Szilvassy S, Slany R, Cleary ML
Immortalization and leukemic transformation of a myelomonocytic
precursor by retrovirally transduced HRX-ENL.
EMBO J 16:4226-4237, 1997.
Morrissey
JJ, Raney S, Cleary ML
The Fel (AF-4) protein donates potent transcriptional activating
sequences to the Hrx-Fel fusion protein in leukemias resulting from t(4;11)(q21;q23)
chromosomal translocations.
Leuk Res 21:911-917, 1997.
Butler
LH, Slany R, Cui X, Cleary ML, Mason DY
The HRX proto-oncogene product is widely expressed in human tissues
and localises to nuclear structures.
Blood 89:3361-3370, 1997.
Hunger
SP, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn JL, Willman C,
Cleary ML
HRX involvement in de novo and secondary leukemias with diverse
chromosome 11q23 abnormalities.
Blood 81:3197-3203, 1993.
Rubnitz
JE, Morrissey J, Savage PA, Cleary ML
ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear
protein with transcriptional activation potential in lymphoid and myeloid
cells.
Blood 84:1747-1752, 1994.
Rubnitz
JE, Link,MP, Shuster JJ, Carroll AJ, Hakami N, Frankel LS, Pullen DJ, Cleary
ML
Frequency and prognostic significance of HRX rearrangements in infant
acute lymphoblastic leukemia: A Pediatric Oncology Group study.
Blood 84:570-573, 1994.
De
Vivo ID, Cui X, Domen J, Cleary ML
Growth stimulation of primary B cell precursors by the anti-phosphatase
Sbf1.
Proc Natl Acad Sci USA 95:9471-9476, 1998.
Cui
X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML
Association of SET domain and myotubularin-related proteins modulates
growth control.
Nat Genet 18:331-337, 1998.
Kasper
LH, Brindle PK, Schnabel CA, Pritchard CEJ, Cleary ML, van Deursen JMA
CREB binding protein interacts with nucleoporin-specific FG-repeats
that activate transcription and mediate NUP98-HOXA9 oncogenicity.
Mol Cell Biol 19:764-776, 1999.
Feldman
BJ, Reid TR, Cleary ML
Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic
lymphomas in transgenic mice.
Oncogene 15:2735-2742, 1997.
Smith
KS, Jacobs Y, Chang C-P, Cleary, ML
Chimeric oncoprotein E2a-Pbx1 induces apoptosis of hematopoietic
cells by a p53-independent mechanism that is suppressed by Bcl-2.
Oncogene 14:2917-2926, 1997.
Chang
C-P, De Vivo I, Cleary ML
The Hox cooperativity motif of chimeric oncoprotein E2a-Pbx1 is
necessary and sufficient for oncogenesis.
Mol Cell Biol 17:81-88, 1997.
Monica
K, LeBrun DP, Dedera DA, Brown R, Cleary ML
Transformation properties of the E2a-Pbx1 chimeric oncoprotein:
Fusion with E2a is essential but the Pbx1 homeodomain is dispensible.
Mol Cell Biol 14:8304-8313, 1994.
Hunger
SP, Brown R, Cleary ML
DNA-binding and transcriptional regulatory properties of Hepatic
Leukemia Factor (HLF) and the t(17;19)-acute lymphoblastic leukemia chimera
E2A-HLF.
Mol Cell Biol 14:5986-5996, 1994.
Dedera
DA, Waller EK, LeBrun DP, Sen-Majumbar A, Stevens ME, Barsh GS,Cleary ML
Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis,
and malignant lymphomas in transgenic mice.
Cell 74: 833-843, 1993.
Morrissey
J, Tkachuk DC, Milatovich A, Francke U, Link M, Cleary ML
A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.
Blood 81:1124-1131, 1993.
Tkachuk
DC, Kohler S, Cleary ML
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal
translocations in acute leukemias.
Cell 71:691-700, 1992.
Hunger
SP, Ohyashiki K, Toyama K, Cleary ML
HLF, a novel hepatic bZIP protein, shows altered DNA-binding properties
following fusion to E2A in t(17;19) - ALL.
Genes & Dev 6:1608-1620, 1992.
Cleary ML
Oncogenic conversion of transcription factors by chromosomal translocations.
Cell 66: 619-622, 1991.
Hunger
SP, Galili NG, Carroll AJ, Crist WM, Link MP, Cleary ML
The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1
coding sequences in acute lymphoblastic leukemias.
Blood 77:687-693, 1991.
Nourse
J, Mellentin JD, Galili N, Wilkinson J, Stanbridge E, Smith SD, Cleary
ML
Chromosomal translocation t(1;19) results in synthesis of a homeobox
fusion mRNA that codes for a potential chimeric transcription factor.
Cell 60:535-545, 1990.