skip to: page content | links on this page | site navigation | footer (site information)

Blau Lab

Publications

small logo

Stem Cells / Niche / Nuclear Reprogramming

Palermo, A.T., LaBarge, M.A., Doyonnas, R., Pomerantz, J., and Blau, H.M. (2005) Bone marrow to muscle: a transplantation-independent physiological response to localized stress. Devel. Biol. 279:336-344.

Doyonnas, R., LaBarge, M.A., Sacco, A., Charlton, C. and Blau, H.M. (2004) Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors.  Proc. Natl. Acad. Sci. USA 101(37) :13507-13512. Abstract

Pomerantz, J. and Blau, H.M. (2004) Nuclear reprogramming:  A key to regenerative medicine.  Nature Cell Biol. 6 :810-816. Abstract

Corbel, S.Y., Lee, A., Yi, L., Duenas, J., Brazelton, T.R., Blau, H.M. and Rossi, F.M.V. (2003) Contribution of hematopoietic stem cells to skeletal muscle. Nature Medicine 9(12) :1528-1532. Abstract

Weimann, J.M., Johansson, C.B., Trejo, A. and Blau, H.M. (2003) Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons in adult brain after BMT. Nature Cell Biol. 5(11) :959-966. Abstract

Brazelton, T.R., Nystrom M. and Blau, H.M. (2003).Significant differences among skeletal muscles in the incorporation of bone marrow-derived cells. Dev. Biol. 262(1) :64-74. Abstract

Weimann, J.M., Charlton, C.A., Brazelton, T.R., Hackman, R.C. and Blau, H.M.(2003) Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc. Nat. Acad. Sci. USA 100 : 2088-2093. Abstract

LaBarge, M.A. and Blau, H.M.(2002) Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury. Cell 111 :589-601. Abstract

Blau, H.M., Brazelton, T., Keshet, G. and Rossi, F. (2002) Something in the eye of the beholder.  Science 298 :361-362.

Blau, H.M. (2002) A twist of fate.  Nature 419 :437.

Munz, B., Hildt, E., Springer, M.L. and Blau, H.M. (2002) RIP2, a checkpoint in myogenic differentiation.  Mol. Cell. Biol. 22(16) :5879-5886. Abstract
View or download a reprint of this article from the Web

Springer, M.L., Ozawa, C.R. and Blau, H.M. (2002) Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation.  Cell Motil Cytoskeleton 51 :177-186.

Blau, H.M., Brazelton, T.R. and Weimann, J.M. (2001) The evolving concept of a stem cell: Entity or function? Cell 105, 1-20. View or download a reprint of this article from the Web

Springer, M.L., Brazelton, T.R. and Blau, H.M. (2001) Not the usual suspects: the unexpected sources of tissue regeneration. J. Clinical Invest. 107, 1355-1356. View or download a reprint of this article from the Web

Brazelton, T.R., Rossi, F. M. V., Keshet, G.I. and Blau, H.M. (2000) From marrow to brain: Expression of neuronal phenotypes in adult mice. Science 290, 1775-1779. View or download a reprint of this article from the Web

Blau, H. M. (1992). Differentiation requires continuous active control. Annu Rev Biochem 61, 1213-30. Abstract

Blau, H. M., & Baltimore, D. (1991). Differentiation requires continuous regulation. J Cell Biol 112, 781-3.

Blau, H. M. (1989). How fixed is the differentiated state? Lessons from heterokaryons. Trends Genet 5, 268-72. Abstract

Pavlath, G. K., Chiu, C. P., & Blau, H. M. (1989). In vivo aging of human fibroblasts does not alter nuclear plasticity in heterokaryons. Somat Cell Mol Genet 15, 191-202. Abstract

Miller, S. C., Pavlath, G. K., Blakely, B. T., & Blau, H. M. (1988). Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons. Genes Dev 2, 330-40. Abstract

Pavlath, G. K., & Blau, H. M. (1986). Expression of muscle genes in heterokaryons depends on gene dosage. J Cell Biol 102, 124-30. Abstract

Hardeman, E. C., Chiu, C. P., Minty, A., & Blau, H. M. (1986). The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced. Cell 47, 123-30. Abstract

Chiu, C. P., & Blau, H. M. (1985). 5-Azacytidine permits gene activation in a previously noninducible cell type. Cell 40, 417-24. Abstract

Blau, H. M., Pavlath, G. K., Hardeman, E. C., Chiu, C. P., Silberstein, L., Webster, S. G., Miller, S. C., & Webster, C. (1985). Plasticity of the differentiated state. Science 230, 758-66. Abstract

Chiu, C. P., & Blau, H. M. (1984). Reprogramming cell differentiation in the absence of DNA synthesis. Cell 37, 879-87. Abstract

Blau, H. M., Chiu, C. P., & Webster, C. (1983). Cytoplasmic activation of human nuclear genes in stable heterocaryons. Cell 32, 1171-80. Abstract

Technology

Wehrman, T.S., Kleaveland, B.M., Her, J-H., Balint, R. and Blau, H.M. (2002) Protein-protein interactions monitored in mammalian cells via complementation of beta-lactamase enzyme fragments, Proc. Natl. Acad. Sci. USA 99, 3469-3474. View or download a reprint of this article from the Web

Charlton, C.A., Mohler, W.A., and Blau, H.M. (2000) Neural cell adhesion molecule (NCAM) and myoblast fusion. Devel. Biol. 221, 112-119. View or download a reprint of this article from the Web

Rossi, F.M.V., Kringstein, A.M, Guicherit, O.M., Spicher, A. and Blau, H.M. (2000) Rheostat mechanism of transcriptional regulation converted to on/off switch. Mol. Cell 6, 723-728. View or download a reprint of this article from the Web

Rossi, F. M., Blakely, B. T., & Blau, H. M. (2000). Interaction blues: protein interactions monitored in live mammalian cells by beta-galactosidase complementation. Trends Cell Biol 10, 119-122. View or download a reprint of this article in PDF format

Blakely, B. T., Rossi, F. M., Tillotson, B., Palmer, M., Estelles, A., & Blau, H. M. (2000). Epidermal growth factor receptor dimerization monitored in live cells. Nat Biotechnol 18, 218-222. Abstract
View or download a reprint of this article in PDF format

Blau, H. M., & Rossi, F. M. (1999). Tet B or not tet B: advances in tetracycline-inducible gene expression. Proc Natl Acad Sci U S A 96, 797-799. View or download a reprint of this article in PDF format

Rossi, F. M., Guicherit, O. M., Spicher, A., Kringstein, A. M., Fatyol, K., Blakely, B. T., & Blau, H. M. (1998). Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Nat Genet 20, 389-393. Abstract
View or download a reprint of this article in PDF format

Rossi, F. M., & Blau, H. M. (1998). Recent advances in inducible gene expression systems. Curr Opin Biotechnol 9, 451-456. Abstract
View or download a reprint of this article in PDF format

Kringstein, A. M., Rossi, F. M., Hofmann, A., & Blau, H. M. (1998). Graded transcriptional response to different concentrations of a single transactivator. Proc Natl Acad Sci U S A 95, 13670-13675. Abstract
View or download a reprint of this article in PDF format

Charlton, C. A., Mohler, W. A., Radice, G. L., Hynes, R. O., and Blau, H. M. (1997). Fusion competence of myoblasts rendered genetically null for N-cadherin in culture. J Cell Biol 138, 331-336. Abstract
View or download a reprint of this article in PDF format

Springer, M. L. and Blau, H. M. (1997). High-efficiency retroviral infection of primary myoblasts. Som. Cell. Mol. Genet. 23, 203-209. Abstract

Yang, J. T., Rando, T. A., Mohler, W. A., Rayburn, H., Blau, H. M., & Hynes, R. O. (1996). Genetic analysis of alpha 4 integrin functions in the development of mouse skeletal muscle. J Cell Biol 135, 829-835.Abstract

Other Recent Work - RNAi

Sen, G., Wehrman, T.S., Myers, J. and Blau, H.M. (2004) Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nature Genetic 36(2) :183-9. Abstract

Other Recent Work - Angiogenesis

Jacobi, J., Sydow K., von Degenfeld, G., Zhang, Y., Hayan Dayoub, H., Bingyin Wang B., Patterson, A.J., Kimoto, M., Blau, H.M., and Cooke, J.P. (2004) Overexpression of dimethylarginine dimethlaminohydrolase (DDAH) reduces tissue ADMA levels and enhances angiogenesis. Circulation 111(11)1421_1438.

Jacobi, J., Tam, B.Y.Y., Sundram, U., von Degenfeld, G., Blau, H.M. Kuo, C. J. and Cooke, J.P. (2004) Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis. Gene Therapy 11 :302-309. Abstract

Ozawa, C.R., Banfi, A., Glazer, N., Thurston, G., Springer, M.L., Kraft, P.E., McDonald, D.M. and Blau, H.M. (2004) Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J. Clin. Invest. 113(4) :516-27. Abstract

Springer, M.L., Ozawa, C.R., Banfi, A., Kraft, P.E., Ip, T.K., Brazelton, T.R. and Blau, H.M. (2003). Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle. Mol. Ther. 7, 441-449. Abstract

von Degenfeld, G., Banfi, A., Springer, M.L. and Blau, H.M. (2003) Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis. Brit. J. Pharm. 140 :620626. Abstract

Koransky, M.L., Robbins, R.C. and Blau, H.M. (2002) VEGF gene delivery for treatment of ischemic cardiovascular disease. Trends In Cardiovasc. Med. 12, 108-114 .Abstract
View or download a reprint of this article from the Web

Blau, H.M. and Banfi, A. (2001) The well-tempered vessel.Nature Medicine 7, 532-534. View or download a reprint of this article from the Web

Springer, M.L., Hortelano, G., Bouley, D., Wong, J., Kraft, P.E. and Blau, H.M. (2000) Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. J. Gene Med. 2, 279-288. View or download a reprint of this article from the Web

Lee, R.J., Springer, M.L., Blanco-Bose, W.E., Shaw, R., Ursell, P.C. and Blau, H.M. (2000) VEGF gene delivery to myocardium: Deleterious effects of unregulated expression. Circulation 102, 898-901. View or download a reprint of this article from the Web

Springer, M.L., Ip, T.K. and Blau, H.M. (2000)  Angiogenesis monitored by perfusion with a space-filling microbead suspension.  Mol. Therapy 1:82-87.Abstract

Other

  • Wehrman, T.S., Kleaveland, B.M., Her, J-H., Balint, R. and Blau, H.M. (2002) Protein-protein interactions monitored in mammalian cells via complementation of beta-lactamase enzyme fragments, Proc. Natl. Acad. Sci. USA. 99 :3469-3474 View or download a reprint of this article from the Web

  • Blau, H.M., Brazelton, T.R. and Weimann, J.M. (2001) The evolving concept of a stem cell: Entity or function? Cell 105 :1-20. View or download a reprint of this article from the Web

  • Springer, M.L., Brazelton, T.R. and Blau, H.M. (2001) Not the usual suspects: the unexpected sources of tissue regeneration. J. Clin. Invest. 107 :1355-1356. View or download a reprint of this article from the Web

  • Blanco-Bose, W.E. and Blau, H.M. (2001) Laminin-induced change in conformation of pre-existing alpha-7beta-1 integrin signals secondary myofiber formation. Dev. Biol. 233 :148-160 View or download a reprint of this article from the Web

  • Blanco-Bose, W.E., Yao, C.-C., Kramer, R.H. and Blau, H.M. (2001) Purification of mouse primary myoblasts based on alpha-7 integrin expression. Exp. Cell Res. 265 :212-220. View or download a reprint of this article from the Web

  • Blau, H.M. and Banfi, A. (2001) The well-tempered vessel. Nature Medicine 7 :532-534. View or download a reprint of this article from the Web

  • Brazelton, T.R., Rossi, F. M. V., Keshet, G.I. and Blau, H.M. (2000) From marrow to brain: Expression of neuronal phenotypes in adult mice. Science 290 :1775-1779. View or download a reprint of this article from the Web

  • Charlton, C.A., Mohler, W.A., and Blau, H.M. (2000) Neural cell adhesion molecule (NCAM) and myoblast fusion. Dev. Biol. 221: :112-119 View or download a reprint of this article from the Web

  • Springer, M.L., Hortelano, G., Bouley, D., Wong, J., Kraft, P.E. and Blau, H.M. (2000) Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. J. Gene Med. 2: :279-288. View or download a reprint of this article from the Web

  • Lee, R.J., Springer, M.L., Blanco-Bose, W.E., Shaw, R., Ursell, P.C. and Blau, H.M. (2000) VEGF gene delivery to myocardium: Deleterious effects of unregulated expression. Circulation 102 :898-901. View or download a reprint of this article from the Web

  • Rossi, F.M.V., Kringstein, A.M, Guicherit, O.M., Spicher, A. and Blau, H.M. (2000) Rheostat mechanism of transcriptional regulation converted to on/off switch. Mol. Cell 6 :723-728. View or download a reprint of this article from the Web

  • Rossi, F. M., Blakely, B. T., and Blau, H. M. (2000). Interaction blues: protein interactions monitored in live mammalian cells by beta-galactosidase complementation. Trends Cell Biol 10 :119-122. View or download a reprint of this article in PDF format

  • Blakely, B. T., Rossi, F. M., Tillotson, B., Palmer, M., Estelles, A., and Blau, H. M. (2000). Epidermal growth factor receptor dimerization monitored in live cells. Nat Biotechnol 18 :218-222. Abstract
    View or download a reprint of this article in PDF format

  • Springer, M.L., Ip, T.K. and Blau, H.M. (2000)  Angiogenesis monitored by perfusion with a space-filling microbead suspension.  Mol. Therapy 1 :82-87. Abstract

  • Abendroth, A., Slobedman, B., Springer, M. L., Blau, H. M., and Arvin, A. M. (1999). Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination. Antiviral Res 44 :179-192. Abstract

  • Estelles, A., Charlton, C. A., and Blau, H. M. (1999). The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1- mediated caspase-8 activity and apoptosis. Dev Biol. 216 :16-28. Abstract
    View or download a reprint of this article in PDF format

  • Blau, H. M.,and Rossi, F. M. (1999). Tet B or not tet B: advances in tetracycline-inducible gene expression. Proc Natl Acad Sci U S A 96 :797-799. View or download a reprint of this article in PDF format

  • Springer, M. L., Kraft, P. E., and Blau, H. M. (1998). Inhibition of solid tumor growth by Fas ligand-expressing myoblasts. Somat Cell Mol Genet 24 :281-289. Abstract

  • Fridman, J. S., Rehemtulla, A., Hofmann, A., Blau, H. M., and Maybaum, J. (1998). Expression of Bcl-XS alters cytokinetics and decreases clonogenic survival in K12 rat colon carcinoma cells. Oncogene 17 :2981-2991. Abstract
    View or download a reprint of this article in PDF format

  • Springer, M. L., Chen, A. S., Kraft, P. E., Bednarski, M., and Blau, H. M. (1998). VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol. Cell 2 :549-558. Abstract
    View or download a reprint of this article in PDF format

  • Rossi, F. M., Guicherit, O. M., Spicher, A., Kringstein, A. M., Fatyol, K., Blakely, B. T., and Blau, H. M. (1998). Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Nat Genet 20 :389-393. Abstract
    View or download a reprint of this article in PDF format

  • Rossi, F. M., and Blau, H. M. (1998). Recent advances in inducible gene expression systems. Curr. Opin. Biotechnol. 9 :451-456. Abstract
    View or download a reprint of this article in PDF format

  • Spicher, A., Guicherit, O. M., Duret, L., Aslanian, A., Sanjines, E. M., Denko, N. C., Giaccia, A. J., and Blau, H. M. (1998). Highly conserved RNA sequences that are sensors of environmental stress. Mol. Cell Biol. 18 :7371-7382. Abstract
    View or download a reprint of this article in PDF format

  • Kringstein, A. M., Rossi, F. M., Hofmann, A., and Blau, H. M. (1998). Graded transcriptional response to different concentrations of a single transactivator. Proc. Natl. Acad. Sci. USA 95 :13670-13675. Abstract
    View or download a reprint of this article in PDF format

  • Hofmann A. and Blau H.M. (1997). Death of solid tumor cells induced by Fas ligand expressing primary myoblasts. Som. Cell Mol. Genet. 23 :249-57. Abstract

  • Kang, S-M, Hofmann, A, Le, D., Springer, M.L., Stock, P.G., and Blau, H.M. (1997). Immune response and myoblasts that express Fas ligand. Science 278 :1322 - 1325. View or download a reprint of this article in PDF format

  • Gussoni, E., Blau, H.M., and Kunkel, L.M. (1997). The fate of individual myoblasts after transplantation into muscles of DMD patients. Nature Medicine 3 :970-978. Abstract

  • Rossi, F., Charlton, C. A., and Blau, H. M. (1997). Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation. Proc. Natl. Acad. Sci. USA 94 :8405-8410. Abstract
    View or download a reprint of this article in PDF format

  • Charlton, C. A., Mohler, W. A., Radice, G. L., Hynes, R. O., and Blau, H. M. (1997). Fusion competence of myoblasts rendered genetically null for N-cadherin in culture. J. Cell Biol. 138 :331-336. Abstract
    View or download a reprint of this article in PDF format

  • Springer, M. L. and Blau, H. M. (1997). High-efficiency retroviral infection of primary myoblasts. Som. Cell. Mol. Genet. 23 :203-209. Abstract

  • Blau, H. M., and Khavari, P. (1997). Gene therapy: progress, problems, and prospects. Nature Medicine 3 :612-13.

  • Miller, R. G., Sharma, K. R., Pavlath, G. K., Gussoni, E., Mynhier, M., Lanctot, A. M., Greco, C.M., Steinman, L., and Blau, H. M. (1997). Myoblast implantation in Duchenne muscular dystrophy: the San Francisco study. Muscle and Nerve 20, 469-78. Abstract

  • Mohler, W. A., and Blau, H. M. (1997). Rapid plasmid minipreps in microplate format from culture to gel. BioTechniques 22 :388-9.

  • Dhawan, J. Rando, T.A., Elson, S.E., Lee, F., Stanley, E.R. and Blau, H.M. (1996). Myoblast-mediated expression of colony stimulating factor-1 (CSF-1) in the cytokine-deficient op/op mouse. Som. Cell Mol. Genet. 22. :363-81. Abstract

  • Rohrer, D. and Blau, H.M. (1996). Defective myogenesis in NFB-s mutant associated with a saturable suppression of myf5 activity. Som. Cell Mol. Genet. 22 :349-361. Abstract

  • Yang, J. T., Rando, T. A., Mohler, W. A., Rayburn, H., Blau, H. M., and Hynes, R. O. (1996). Genetic analysis of alpha 4 integrin functions in the development of mouse skeletal muscle. J. Cell Biol. 135 :829-835. Abstract

  • Gussoni, E., Wang, Y., Fraefel, C., Miller, R.G., Blau, H.M., Geller, A. and Kunkel, L. (1996). A method to codetect introduced genes and their products in gene therapy protocols. Nature Biotechnology 14 :1012-1016. Abstract

  • Mohler, W. A., and Blau, H. M. (1996). Gene expression and cell fusion analyzed by lacZ complementation in mammalian cells. Proc. Natl. Acad. Sci. USA 93 :12423-124237. Abstract

  • Mohler, W. A., Charlton, C. A., and Blau, H. M. (1996). Spectrophotometric quantitation of tissue culture cell number in any medium. BioTechniques 21 :260-266. Abstract

  • Hofmann, A., Nolan, G. P., and Blau, H. M. (1996). Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette [see comments]. Proc. Natl. Acad. Sci. USA 93 :5185-5190. Abstract

  • Dhawan, J., Rando, T. A., Elson, S. L., Bujard, H., and Blau, H. M. (1995). Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle. Somat. Cell Mol. Genet. 21 :233-240. Abstract

  • Blau, H. M., and Springer, M. L. (1995). Muscle-mediated gene therapy. N. Engl. J. Med. 333 :1554-1556.

  • Blau, H. M., and Springer, M. L. (1995). Gene therapy--a novel form of drug delivery. N. Engl. J. Med. 333 :1204-1207.

  • Rando, T. A., Pavlath, G. K., and Blau, H. M. (1995). The fate of myoblasts following transplantation into mature muscle. Exp. Cell Res. 220 :383-389. Abstract

  • Cho, M., Hughes, S. M., Karsch-Mizrachi, I., Travis, M., Leinwand, L. A., and Blau, H. M. (1994). Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception. J. Cell Sci. 107 :2361-2371. Abstract

  • Gussoni, E., Pavlath, G. K., Miller, R. G., Panzara, M. A., Powell, M., Blau, H. M., and Steinman, L. (1994). Specific T cell receptor gene rearrangements at the site of muscle degeneration in Duchenne muscular dystrophy. J. Immunol. 153 :4798-4805. Abstract

  • Rando, T. A., and Blau, H. M. (1994). Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. J. Cell Biol. 125 :1275-1287. Abstract

  • Pavlath, G. K., Rando, T. A., and Blau, H. M. (1994). Transient immunosuppressive treatment leads to long-term retention of allogeneic myoblasts in hybrid myofibers. J. Cell Biol. 127 :1923-1932. Abstract

  • Mohler, W. A., and Blau, H. M. (1994). Membrane-bound neomycin phosphotransferase confers drug-resistance in mammalian cells: a marker for high-efficiency targeting of genes encoding secreted and cell-surface proteins. Somat. Cell Mol. Genet. 20 :153-162. Abstract

  • Cho, M., Webster, S. G., and Blau, H. M. (1993). Evidence for myoblast-extrinsic regulation of slow myosin heavy chain expression during muscle fiber formation in embryonic development. J. Cell Biol. 121 :795-810. Abstract

  • Rohrer, D.K., Rastinejad, F., Hwung, Y.-P. and Blau, H.M. (1993) RNA from the 3' untranslated region a-tropomyosin activates PKR, the double-stranded RNA-dependent protein-kinase. Cell 75 :1-20.

  • Rastinejad, F., and Blau, H. M. (1993). Genetic complementation reveals a novel regulatory role for 3' untranslated regions in growth and differentiation. Cell 72 :903-17. Abstracts

  • Hughes, S. M., Cho, M., Karsch-Mizrachi, I., Travis, M., Silberstein, L., Leinwand, L. A., and Blau, H. M. (1993). Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle. Dev. Biol. 158 :183-99. Abstract

  • Rastinejad, F., Conboy, M. J., Rando, T. A., and Blau, H. M. (1993). Tumor suppression by RNA from the 3' untranslated region of alpha-tropomyosin. Cell 75 :1107-1117. Abstract

  • Blau, H. M., Dhawan, J., and Pavlath, G. K. (1993). Myoblasts in pattern formation and gene therapy. Trends Genet. 9 :269-274. Abstracts

  • Blau, H. M. (1993). Muscular dystrophy. Muscling in on gene therapy [news & views]. Nature 364 :673-675.

  • Hughes, S. M., and Blau, H. M. (1992). Muscle fiber pattern is independent of cell lineage in postnatal rodent development. Cell 68 :659-671. Abstract

  • Pan, L. C., Margolskee, R. F., and Blau, H. M. (1992). Cloning muscle isoforms of neural cell adhesion molecule using an episomal shuttle vector. Somat. Cell Mol. Genet. 18. :163-177. Abstract

  • Gussoni, E., Pavlath, G. K., Lanctot, A. M., Sharma, K. R., Miller, R. G., Steinman, L., and Blau, H. M. (1992). Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation. Nature 356, 435-8. Abstract

  • Blau, H. M. (1992). How cells know their place [news & views]. Nature 358 :284-285.

  • Peterson, C. A., Cho, M., Rastinejad, F., and Blau, H. M. (1992). Beta-enolase is a marker of human myoblast heterogeneity prior to differentiation. Dev. Biol. 151 :626-629. Abstract

  • Blau, H. M. (1992). Differentiation requires continuous active control. Annu. Rev. Biochem. 61 :1213-1230. Abstract

  • Dhawan, J., Pan, L. C., Pavlath, G. K., Travis, M. A., Lanctot, A. M., and Blau, H. M. (1991). Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science 254, 1509-1512. Abstract

  • Blau, H. M., and Baltimore, D. (1991). Differentiation requires continuous regulation. J. Cell Biol. 112 :781-783.

  • Mantegazza, R., Hughes, S. M., Mitchell, D., Travis, M., Blau, H. M., and Steinman, L. (1991). Modulation of MHC class II antigen expression in human myoblasts after treatment with IFN-gamma. Neurology 41 :1128-1132. Abstract

  • Schafer, B. W., Blakely, B. T., Darlington, G. J., and Blau, H. M. (1990). Effect of cell history on response to helix-loop-helix family of myogenic regulators. Nature 344 :454-458. Abstract

  • Kaplan, I., Blakely, B. T., Pavlath, G. K., Travis, M., and Blau, H. M. (1990). Steroids induce acetylcholine receptors on cultured human muscle: implications for myasthenia gravis. Proc. Natl. Acad. Sci. USA 87 :8100-8104. Abstract

  • Peterson, C. A., Gordon, H., Hall, Z. W., Paterson, B. M., and Blau, H. M. (1990). Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant. Cell 62 :493-502. Abstract

  • Condon, K., Silberstein, L., Blau, H. M., and Thompson, W. J. (1990). Differentiation of fiber types in aneural musculature of the prenatal rat hindlimb. Dev. Biol. 138 :275-295. Abstract

  • Condon, K., Silberstein, L., Blau, H. M., and Thompson, W. J. (1990). Development of muscle fiber types in the prenatal rat hindlimb. Dev. Biol. 138 :256-274. Abstract

  • Webster, C., and Blau, H. M. (1990). Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: implications for cell and gene therapy. Somat. Cell Mol. Genet. 16 :557-565. Abstract

  • Hughes, S. M., and Blau, H. M. (1990). Migration of myoblasts across basal lamina during skeletal muscle development. Nature 345. :350-353. Abstract

  • Blau, H. M., and Hughes, S. M. (1990). Cell lineage in vertebrate development. Curr. Opin. Cell Biol. 2 :981-985.

  • Blau, H. M. (1989). How fixed is the differentiated state? Lessons from heterokaryons. Trends Genet. 5 :268-272. Abstract

  • Karsch, M. I., Travis, M., Blau, H., and Leinwand, L. A. (1989). Expression and DNA sequence analysis of a human embryonic skeletal muscle myosin heavy chain gene. Nucleic Acids Res. 17 :6167-6179. Abstract

  • Pavlath, G. K., Chiu, C. P., and Blau, H. M. (1989). In vivo aging of human fibroblasts does not alter nuclear plasticity in heterokaryons. Somat. Cell Mol. Genet. 15 :191-202. Abstract

  • Pavlath, G. K., Rich, K., Webster, S. G., and Blau, H. M. (1989). Localization of muscle gene products in nuclear domains. Nature 337 :570-573. Abstract

  • Webster, C., Silberstein, L., Hays, A. P., and Blau, H. M. (1988). Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. Cell 52 :503-513. Abstract

  • Miller, S. C., Pavlath, G. K., Blakely, B. T., and Blau, H. M. (1988). Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons. Genes Dev. 2 :330-340. Abstract

  • Miller, S. C., Ito, H., Blau, H. M., and Torti, F. M. (1988). Tumor necrosis factor inhibits human myogenesis in vitro. Mol. Cell Biol. 8 :2295-2301. Abstract

  • Ham, R. G., St. Clair, J. A., Webster, C., and Blau, H. M. (1988). Improved media for normal human muscle satellite cells: serum-free clonal growth and enhanced growth with low serum. In Vitro Cell Dev. Biol. 24 :833-844. Abstract

  • Blau, H. M. (1988). Hierarchies of regulatory genes may specify mammalian development. Cell 53 :673-674.

  • Webster, C., Pavlath, G. K., Parks, D. R., Walsh, F. S., and Blau, H. M. (1988). Isolation of human myoblasts with the fluorescence-activated cell sorter. Exp. Cell Res. 174 :252-265. Abstract

  • Hardeman, E. C., Minty, A., Benton-Vosman, P., Kedes, L., and Blau, H. M. (1988). In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function. J. Cell Biol. 106 :1027-1034. Abstract

  • Gunning, P., Hardeman, E., Wade, R., Ponte, P., Bains, W., Blau, H. M., and Kedes, L. (1987). Differential patterns of transcript accumulation during human myogenesis. Mol. Cell Biol. 7 :4100-4114. Abstract

  • Soileau, L. C., Silberstein, L., Blau, H. M., and Thompson, W. J. (1987). Reinnervation of muscle fiber types in the newborn rat soleus. J. Neurosci. 7 :4176-4194. Abstract

  • Pavlath, G. K., and Blau, H. M. (1986). Expression of muscle genes in heterokaryons depends on gene dosage. J. Cell Biol. 102 :124-130. Abstract

  • Webster, C., Filippi, G., Rinaldi, A., Mastropaolo, C., Tondi, M., Siniscalco, M., and Blau, H. M. (1986). The myoblast defect identified in Duchenne muscular dystrophy is not a primary expression of the DMD mutation. Clonal analysis of myoblasts from five double heterozygotes for two X-linked loci: DMD and G6PD. Hum. Genet. 74 :74-80. Abstract

  • Costa, E. M., Blau, H. M., and Feldman, D. (1986). 1,25-dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells. Endocrinology 119 :2214-2220. Abstract

  • Minty, A., Blau, H., and Kedes, L. (1986). Two-level regulation of cardiac actin gene transcription: muscle-specific modulating factors can accumulate before gene activation. Mol. Cell Biol. 6 :2137-2148. Abstract

  • Silberstein, L., Webster, S. G., Travis, M., and Blau, H. M. (1986). Developmental progression of myosin gene expression in cultured muscle cells. Cell 46 :1075-1081. Abstract

  • Hardeman, E. C., Chiu, C. P., Minty, A., and Blau, H. M. (1986). The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced. Cell 47 :123-130. Abstract

  • Kaplan, I. D., and Blau, H. M. (1986). Metabolic properties of human acetylcholine receptors can be characterized on cultured human muscle. Exp. Cell Res. 166. :379-390. Abstract

  • Shimizu, M., Webster, C., Morgan, D. O., Blau, H. M., and Roth, R. A. (1986). Insulin and insulinlike growth factor receptors and responses in cultured human muscle cells. Am. J. Physiol. 251 :E611-E615. Abstract

  • Chiu, C. P., and Blau, H. M. (1985). 5-Azacytidine permits gene activation in a previously noninducible cell type. Cell 40 :417-424. Abstract

  • Blau, H. M., Pavlath, G. K., Hardeman, E. C., Chiu, C. P., Silberstein, L., Webster, S. G., Miller, S. C., and Webster, C. (1985). Plasticity of the differentiated state. Science 230 :758-766. Abstract

  • Bains, W., Ponte, P., Blau, H., and Kedes, L. (1984). Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro. Mol. Cell Biol. 4 :1449-1453. Abstract

  • Chiu, C. P., and Blau, H. M. (1984). Reprogramming cell differentiation in the absence of DNA synthesis. Cell 37 :879-887. Abstract

  • Blau, H. M., Webster, C., Chiu, C. P., Guttman, S., and Chandler, F. (1983). Differentiation properties of pure populations of human dystrophic muscle cells. Exp. Cell Res. 144 :495-503. Abstract

  • Blau, H. M., Kaplan, I., Tao, T. W., and Kriss, J. P. (1983). Thyroglobulin-independent, cell-mediated cytotoxicity of human eye muscle cells in tissue culture by lymphocytes of a patient with Graves' ophthalmopathy. Life Sci. 32. :45-53>

  • Blau, H. M., Webster, C., and Pavlath, G. K. (1983). Defective myoblasts identified in Duchenne muscular dystrophy. Proc. Natl. Acad. Sci. USA 80 :4856-4860. Abstract

  • Gunning, P., Ponte, P., Blau, H., and Kedes, L. (1983). alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart. Mol. Cell Biol. 3 :1985-1995. Abstract

  • Ponte, P., Gunning, P., Blau, H., and Kedes, L. (1983). Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution. Mol. Cell Biol 3 :1783-1791. Abstract

  • Blau, H. M., Chiu, C. P., and Webster, C. (1983). Cytoplasmic activation of human nuclear genes in stable heterocaryons. Cell 32. :1171-1180. Abstract

  • Gunning, P., Ponte, P., Okayama, H., Engel, J., Blau, H., and Kedes, L. (1983). Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol. Cell Biol. 3 :787-795. Abstract

  • Blau, H. M., and Webster, C. (1981). Isolation and characterization of human muscle cells. Proc. Natl. Acad. Sci. USA 78 :5623-5627. Abstract

  • Blau, H. M., and Epstein, C. J. (1979). Manipulation of myogenesis in vitro: reversible inhibition by DMSO. Cell 17 :95-108. Abstract

  • Blau, H. M., and Kafatos, F. C. (1979). Morphogenesis of the silkmoth chorion: patterns of distribution and insolubilization of the structural proteins. Dev. Biol. 72 :211-225.

  • Blau, H. M., and Kafatos, F. C. (1978). Secretory kinetics in the follicular cells of silkmoths during eggshell formation. J. Cell Biol. 78 :131-151. Abstract

 

Contact Us | ©2003 Blau Lab.