Marc E. Levenston

Associate Professor, Department of Mechanical Engineering

Degrees

B.S. University of Florida - Mechanical Engineering (1989)

M.S. Stanford University - Mechanical Engineering (1990)

Ph.D. Stanford University - Mechanical Engineering (1995)

Research Interests

Professor Levenston's research focuses on the function, degeneration and repair of orthopaedic soft tissues, with an emphasis on understanding the interactions between biophysical and biochemical cues in controlling cells from articular cartilage and fibrocartilage. Current research includes studies on tissue mechanics and structure/function relationships, noninvasive analysis of cartilage composition and structure via novel imaging strategies, and the influence of mechanical and biochemical stimuli on cell differentiation and tissue production for tissue engineering applications. Professor Levenston will join the Stanford faculty in January, 2007 following 8 years on the faculty of the School of Mechanical Engineering at the Georgia Institute of Technology.

Awards/Honors

Docteur Honoris Causa, Université Henri Poincaré, Nancy, France (2005)

Editorial Board, Biorheology (2005-)

Negma-Lerads International Prize for Research on Mechanobiology of Cartilage & Chondrocyte (2005)

Lockheed Martin Dean’s Award for Teaching Excellence (2004)

Member, NIH Skeletal Biology Structure and Regeneration Study Section (2003-2007)

CETL/BP Junior Faculty Teaching Excellence Award (2001)

Selected Publications

Hunter, C.J., Malaviya, P., Nerem, R.M. and Levenston, M.E. 2002. Static compression inhibits gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen-I gels. Biomaterials, 23:1249-59.

Hunter, C.J. and Levenston, M.E. 2002. The influence of repair tissue maturation on the response to oscillatory compression in a cartilage defect repair model. Biorheology, 39:79-88.

Hunter, C.J., Mouw, J.K. and Levenston, M.E. 2004. Dynamic compression of chondrocyte-seeded fibrin gels: effects on matrix accumulation and mechanical stiffness. Osteoarthritis and Cartilage, 12:117-30.

Brodkin, K.B., García, A.J. and Levenston, M.E. 2004. Chondrocyte phenotypes on different extracellular matrix monolayers. Biomaterials, 25:5929-38.

Hunter, C.J. and Levenston, M.E. 2004. Maturation and integration of different tissue engineered cartilages within an in vitro defect repair model. Tissue Engineering, 10:736-46.

Connelly, J.T., Vanderploeg, E.J. and Levenston, M.E. 2004. The influence of cyclic tension amplitude on chondrocyte matrix synthesis: experimental and finite element analyses. Biorheology, 41:377-87.

Imler, S.M., Doshi, A.N. and Levenston, M.E. 2004. Combined effects of anabolic cytokines and static mechanical compression on meniscal explant biosynthesis. Osteoarthritis and Cartilage, 12:736-44.

Vanderploeg, E.J., Imler, S.M., Brodkin, K.R., García, A.J. and Levenston, M.E. 2004. Oscillatory tension differentially modulates matrix metabolism and cytoskeletal organization in chondrocytes and fibrochondrocytes. Journal of Biomechanics, 37:1941-42.

Mouw, J.K., Case, N.D., Guldberg, R.E., Plaas, A.H.K. and Levenston, M.E. 2005. Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering. Osteoarthritis and Cartilage, 13:828-36.

Projects

[ BME Division ] [ BME Faculty ] [ Mechanical Engineering Faculty ]