Barron Lab is funded by a number of NIH/NSF Grants from the following institutes:
3/15/06 - 3/14/11
Development of a biomimetic lung surfactant replacement
2 R01 HL067984 (Barron)
The major goals of this project are to develop synthetic "peptoid" (N-substituted glycine) protein mimics for a biomimetic, exogenous lung surfactant replacement, to treat neonatal respiratory distress in premature infants.
Ultrafast DNA sequencing on microfluidic chips: matrices and mechanisms
2 R01 HG001970 (Barron)
The major goals of this project are to create new families of acrylamide-based polymers and co-polymers to serve as DNA separation matrixes for ultra-fast, long-read DNA sequencing on microchips, and perform studies that will allow us to correlate physical properties of the polymers and their networks with performance.
3/15/07 - 2/28/12
Ampetoids as biostable functional mimics of antimicrobial peptides
1 R01 AI072666 (Barron)
The major goals of this project are to create, test, and study biostable, biomimimetic oligo-N-substituted glycine analogues of antimicrobial peptides, and investigate their broad-spectrum activity and selectivity.
6/1/07 - 5/31/09
Fast mutation detection by tandem SSCP/HA on microchips
1 R33 CA9275 (Barron)
The major goals of this project are to pilot/test a microfluidic chip-based screen for DNA sequence alterations in the p53 gene of clinical patient samples.
9/1/04 - 8/31/09
Catalytic manipulation of amide-based molecules and materials
L474530 // CHE-0404704 (Gellman)
(Subcontract from University of Wisconsin-Madison)
The goals of this project are to test a novel class of amide-based polymers (b-peptides from Gellman) as mimics of lung surfactant proteins.
9/4/04 - 8/31/09
Regenerative scaffold technologies for CNS and diabetes
5 R01 EB003806 (Stupp)
The goals of this project are to create protein-based hydrogels for in vivo sequestration/immune protection of b-islet, insulin-secreting cells, and test these materials in transplantation studies with mice.
Genotyping molecular signatures of CRC using polymer-microchip CE and FSCE
1 R21 CA12867-01 (Soper)
The goals of this project are to develop a new technology for genotyping human colorectal cancer samples using free-solution bioconjugate electrophoresis on plastic microfluidic devices. Soper lab is designing the assay and creating plastic microfluidic devices; Barron lab is synthesizing poly-N-methoxyethylglycine-based "drag-tags" that are monodisperse, pure, and can be conjugated end-on to oligonucleotide primers near "hot-spot" mutation regions relevant to colorectal cancer. Drag-tags are provided for Soper lab testing on chips.