Publications:

Research
Reviews, Commentary, Chapters

Research (top)

• Ducuing A, Mollereau B, Axelrod JD, Vincent, S. (2013) Absolute requirement of cholesterol binding for Hedgehog gradient formation in Drosophila. Biology Open 0, 1-9 (Free Online) doi: 10.1242/bio.20134952.
  

• Vladar E, Bayly RD, Sangoram A, Scott M & Axelrod JD. (2012) Microtubules enable the planar cell polarity of airway cilia. Current Biology 22, 2203-12 (PDF) http://dx.doi.org/10.1016/j.cub.2012.09.046. Supporting Online Material: (3.4MB PDF)
  

• Abate A, Vincent S, Dobbe R, Silletti A, Axelrod JD & Tomlin CJ. (2012) A mathematical model to study the dynamics of ephtielial cell networks. IEEE/ACM Transactions on Computational Biology and Bioinformatics 9, 1607-20 (PDF) doi 10.1109/TCBB.2012.126. Supplementary simulation output movies available here.
  

• Peng Y, Han C, Axelrod JD. (2012) Planar polarized protrusions break the symmetry of EGFR signaling during Drosophila bract cell fate induction. Developmental Cell 23, 507-518. (PDF) http://dx.doi.org/10.1016/j.devcel.2012.07.016.
  Supporting Online Material: (2.9MB PDF)

• Matis M, Axelrod JD, and Galic M (2012) A universal analysis tool for the detection of asymmetric signal distribution in microscopic images. Developmenatal Dynamics 241, 1301-9. Free PDF Epub date 2012/06/13. doi: 10.1002/dvdy.23818
  

• Tao, H, Inouea, K, Kiyonaria, H, Bassuk, AG, Axelrod, JD, Sasaki, H, Aizawa, S, Ueno, N (2012) Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol 364(2), 138-48. PDF doi.org/10.1016/j.ydbio.2012.01.025
  

• Stubbs JL, Vladar EK, Axelrod JD, & Kintner C (2012) Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Nat Cell Biol. 14(2), 140-7. PDF doi: 10.1038/ncb2406.
  

• Tao, H., Manak, J.R., Sowers, L., Mei, X., Kiyonari, H., Abe, T., Dahdaleh, N.S., Yang, T., Wu, S., Chen, S., Fox, M.H., Gurnett, C., Montine, T., Bird, T., Shaffer, L.G., Rosenfeld, J.A., McConnell, J., Madan-Khetarpal, S., Berry-Kravis, E., Griesbach, H., Saneto, R.P., Scott, M.P., Antic, D., Reed, J., Boland, R., Ehaideb, S.N., El-Shanti, H., Mahajan, V.B., Ferguson, P.J., Axelrod, J.D., Lehesjoki, A.E., Fritzsch, B., Slusarski, D.C., Wemmie, J., Ueno, N., & Bassuk, A.G. (2011) Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans. American Journal of Human Genetics Feb 11;88(2):138-49. Free PDF doi:10.1016/j.ajhg.2010.12.012
  

• Silletti, A., Abate, A., Axelrod, J.D., Tomlin, C.J. (2011) Versatile spectral methods for point set matching. Pattern Recognition Letters 32(5), 731-739. PDF doi:10.1016/j.patrec.2010.11.022
  

• Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, & Axelrod JD (2010) Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis. PLoS ONE 5(2), e8999. Free PDF doi:10.1371/journal.pone.0008999
  

• de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, & Rabinovitch M (2009) Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. Journal of Cell Biology 184, 183-99. Free PDF doi:10.1083/jcb.200806049
  

• Ma, D., Amonlirdviman, K., Raffard, R.L., Abate, A., Tomlin, C.J., Axelrod, J.D. (2008) Cell packing influences planar cell polarity signaling. Proc. Natl. Acad. Sci. 105, 18800-18805. Free PDF doi:10.1073/pnas.0808868105

• Bassuk, A.G., Wallace, R.H., Buhr, A., Buller, A.R., Afawi, Z., Shimojo, M., Miyata, S., Chen, S., Gonzalez-Alegre, P., Griesbach, H.L., Wu, S., Nashelsky, M., Vladar, E.K., Antic, D., Ferguson, P.J., Cirak, S., Voit, T., Scott, M.P., Axelrod, J.D., Gurnett, C., Daoud, A.S., Kivity, S., Neufeld, M.Y., Mazarib, A. Strasssberg, R., Walid, S., Korczyn, A.D., Slusarski, D.C., Berkovic, S.F., El-Shanti, H.I. (2008) A Homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. American Journal of Human Genetics 83, 572-81. Free PDF doi:10.1016/j.ajhg.2008.10.003

• Vincent, S., Perrimon, N. and Axelrod, J.D. (2008) Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development 135, 2767-2775. Free PDF doi:10.1242/dev.017814
  

• Chen, W.-S., Antic, D., Matis, M. Logan, C.Y., Povelones, M., Anderson, G.A., Nusse, R., Axelrod, J.D. (2008) Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling. Cell 133, 1093-1105. Free PDF DOI 10.1016/j.cell.2008.04.048
  Supplemental Online Material: (Free PDF)

• Raffard, R., Amonlirdviman, K., Axelrod, J.D. and Tomlin, C. (2008) An Adjoint-based Parameter Identifcation Algorithm applied to Planar Cell Polarity Signaling. Joint Issue of IEEE Transactions on Circuits and Systems and IEEE Transactions on Automatic Control January, 2008, 109-121. PDF

• Deans, M.R., Antic, D., Suyama, K., Scott, M.P., Axelrod, J.D. and Goodrich, L.V. (2007) Asymmetric distribution of Prickle-Like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Journal of Neuroscience 27, 3139-3147. Free PDF DOI:10.1523/JNEUROSCI.5151-06.2007

• Guan, J., Li, H., Rogulja, A., Axelrod, J.D. and Cadigan, K.M. (2007) The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Dev Biol. 303, 16-28. Free PDF doi:10.1016/j.ydbio.2006.10.028.

• Raffard, R., Amonlirdviman, K., Axelrod, J. D., and Tomlin, C. J. (2006) Automatic Parameter Identification via the Adjoint Method, with Application to Understanding Planar Cell Polarity. In the Proceedings of the 45th IEEE Conference on Decision and Control, San Diego

• Kovoor, A., Seyffarth, P., Ebert, J., Barghashoon, S., Chen, C.K., Schwarz, S., Axelrod, J.D., Simon, M.I., Lester, H.A., Schwarz, J. (2005) D2-dopamine receptors colocalize RGS9-2 via the RGS9 DEP domain and RGS9 knockout mice develop dyskinesias associated with dopamine pathways. Journal of Neuroscience 25, 2157-2165. Free PDF

• Amonlirdviman, K., Khare, N.A., Tree, D.R.P., Chen, W.-S., Axelrod, J.D. and Tomlin, C.J. (2005) Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science 307, 423-426. Free PDF
  Supporting Online Material: (19MB high resolution PDF) or (5.3MB low resolution PDF)

• Ma, D., Yang, C.H., McNeill, H., Simon, M.A. and Axelrod, J.D. (2003) Fidelity in planar cell polarity signalling. Nature 421, 543-547. PDF

• Tree, D.R., Shulman, J.M., Rousset, R., Scott, M.P., Gubb, D. and Axelrod, J.D. (2002) Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell 109, 371-381. Free PDF

• Yang, C.H., Axelrod, J.D. and Simon, M.A. (2002) Regulation of Frizzled by Fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108, 675-688. Free PDF

• Winter, C.G., Wang, B., Ballew, A., Royou, A., Karess, R., Axelrod, J.D. and Luo, L. (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105, 81-91. Free PDF

• Rousset, R., Mack, J.A., Wharton, K.A., Jr., Axelrod, J.D., Cadigan, K.M., Fish, M.P., Nusse, R. and Scott, M.P. (2001) naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev 15, 658-671. Free PDF

• Axelrod, J.D. (2001) Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev 15, 1182-1187. Free PDF

• Axelrod, J.D., Miller, J.R., Shulman, J.M., Moon, R.T. and Perrimon, N. (1998) Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev 12, 2610-2622. Free PDF

• Rulifson, E.J., Micchelli, C.A., Axelrod, J.D., Perrimon, N. and Blair, S.S. (1996) wingless refines its own expression domain on the Drosophila wing margin. Nature 384, 72-74. PDF

• Park, M., Wu, X., Golden, K., Axelrod, J.D. and Bodmer, R. (1996) The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol 177, 104-116. Free PDF

• Klingensmith, J., Yang, Y., Axelrod, J.D., Beier, D.R., Perrimon, N. and Sussman, D.J. (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev 58, 15-26. PDF

• Axelrod, J.D., Matsuno, K., Artavanis-Tsakonas, S. and Perrimon, N. (1996) Interaction between Wingless and Notch signaling pathways mediated by Dishevelled. Science 271, 1826-1832. PDF

• Benjamin, R.J., Linsley, L., Axelrod, J.D., Churchill, W.H., Sieff, C., Shulman, L.N., Elias, A., Ayash, L., Malachowski, M.E., Uhl, L. and et al. (1995) The collection and evaluation of peripheral blood progenitor cells sufficient for repetitive cycles of high-dose chemotherapy support. Transfusion 35, 837-844.

• Axelrod, J.D., Reagan, M.S. and Majors, J. (1993) GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo. Genes Dev 7, 857-869. Free PDF

• Axelrod, J.D., Majors, J. and Brandriss, M.C. (1991) Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo. Mol Cell Biol 11, 564-567. Free PDF

• Axelrod, J.D. and Majors, J. (1989) An improved method for photofootprinting yeast genes in vivo using Taq polymerase. Nucleic Acids Res 17, 171-183. Free PDF

• Lacey, D.L., Axelrod, J., Chappel, J.C., Kahn, A.J. and Teitelbaum, S.L. (1987) Vitamin D affects proliferation of a murine T helper cell clone. J Immunol 138, 1680-1686.

• Axelrod, J.D. and Pilch, P.F. (1983) Unique cytochalasin B binding characteristics of the hepatic glucose carrier. Biochemistry 22, 2222-2227.

• Pilch, P.F., Axelrod, J.D., Colello, J. and M.P. Czech, M.P. (1981) Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation. J Biol Chem 256, 1570-1575. Free PDF

Reviews, Commentary, Chapters (top)

• Axelrod, J.D. (2012) Remodeling a tissue: subtraction adds insight. Science Signaling 5, pe52 (Free PDF) 10.1126/scisignal.2003620. (Free Full Online Text)

• Peng, Y., Axelrod, J.D. (2012) Asymmetric protein localization in planar cell polarity: mechanisms, puzzles, and challenges. Current Topics in Developmental Biology 101, 33-53 (PDF) doi: 10.1016/B978-0-12-394592-1.00002-8.

• Bayly, R., Axelrod, J.D. (2011) Pointing in the right direction: new developments in the field of planar cell polarity. Nature Reviews Genetics 12, 385-391 (PDF) doi:10.1038/nrg2956.

• Axelrod, J.D., Tomlin, C.J. (2011) Modeling the control of planar cell polarity. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. DOI: 10.1002/wsbm.138. PDF

• Axelrod, J.D. (2010) Delivering the lateral inhibition punchline; it's all about the timing. Sci Signal. 2010 Oct 26;3(145):pe38. PDF

• Vladar, E.K., Antic, D., and Axelrod, J.D. (2009) Planar Cell Polarity Signaling: The Developing Cell's Compass. Cold Spring Harb Perspect Biol, 1:a002964 [Epub ahead of print]. PDF

• Axelrod, J.D. (2009) Progress and challenges in understanding planar cell polarity signaling. Seminars in Cell and Developmental Biology 20, 964-971. PDF

• Axelrod, J.D. (2008) Bad hair days for PCP mutants. Nature Cell Biology 10, 1251-1253. PDF

• Vladar, E.K., Axelrod, J.D. (2008) Dishevelled links basal body docking and orientation in ciliated epithelial cells. Trends in Cell Biology 18, 517-520. PDF

• Axelrod, J.D. (2008) Basal bodies, kinocilia and planar cell polarity. Nature Genetics 40, 10-11. PDF

• Tomlin, C.J., Axelrod, J.D. (2007) Biology by numbers: mathematical modelling in developmental biology. Nature Reviews Genetics 8, 331-340. PDF

• Axelrod, J.D. (2006) Cell shape in proliferating epithelia: a multifaceted problem. Cell 126, 643-645. PDF

• He, X. and Axelrod, J.D. (2006) A WNTer wonderland in Snowbird. Development 133, 2597-2603. PDF

• Tomlin, C.J., Axelrod, J.D. (2005) Understanding biology by reverse engineering the control. Proc Natl Acad Sci 102, 4219-4220. PDF

• Veeman, M.T., Axelrod, J.D. and Moon, R.T. (2003) A second canon: functions and mechanisms of β-catenin-independent Wnt signaling. Dev Cell 5, 367-377. PDF

• Tree, D.R., Ma, D. and Axelrod, J.D. (2002) A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol 13, 217-224. PDF

• Axelrod, J.D. (2002) Strabismus comes into focus. Nat Cell Biol 4 E6-8. PDF

• Axelrod, J.D. and McNeill, H. (2002) Coupling planar cell polarity signaling to morphogenesis. ScientificWorldJOURNAL 2, 434-454. PDF DOI 410.1100/tsw.2002.1105

• Shulman, J.M., Perrimon, N. and Axelrod, J.D. (1998) Frizzled signaling and the developmental control of cell polarity. Trends Genet 14, 452-458. PDF

• Meunier-Powell, J., Sanabria, J.A. and Axelrod, J. (1993) Agrobacterium tumefaciens (or Agrobacterium radiobacter) septicemia in a patient with cervical carcinoma. Clinical Microbiology Newsletter 15, 6-7.

• Pilch, P.F., Axelrod, J. and Czech, M.P. Biological properties of a proteolytically altered insulin receptor, in Serono Symposium: Current Views on Insulin Receptors, Andreani, Depirro, Lauro, Olefski and Roth, Editors. 1982, Academic Press: New York. p. 555-560.