Axelrod Lab
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Research (top)

  • de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, & Rabinovitch M (2009) Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. Journal of Cell Biology 184, 183-99. PDF doi:10.1083/jcb.200806049

  • Ma, D., Amonlirdviman, K., Raffard, R.L., Abate, A., Tomlin, C.J., Axelrod, J.D. (2008) Cell packing influences planar cell polarity signaling. Proc. Natl. Acad. Sci. 105, 18800-18805. PDF doi:10.1073/pnas.0808868105
    Supporting Online Information: ( PDF)

  • Bassuk, A.G., Wallace, R.H., Buhr, A., Buller, A.R., Afawi, Z., Shimojo, M., Miyata, S., Chen, S., Gonzalez-Alegre, P., Griesbach, H.L., Wu, S., Nashelsky, M., Vladar, E.K., Antic, D., Ferguson, P.J., Cirak, S., Voit, T., Scott, M.P., Axelrod, J.D., Gurnett, C., Daoud, A.S., Kivity, S., Neufeld, M.Y., Mazarib, A. Strasssberg, R., Walid, S., Korczyn, A.D., Slusarski, D.C., Berkovic, S.F., El-Shanti, H.I. (2008) A Homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. American Journal of Human Genetics 83, 572-81. PDF doi:10.1016/j.ajhg.2008.10.003

  • Vincent, S., Perrimon, N. and Axelrod, J.D. (2008) Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development 135, 2767-2775. PDF doi:10.1242/dev.017814
    Development Homepage

  • Chen, W.-S., Antic, D., Matis, M. Logan, C.Y., Povelones, M., Anderson, G.A., Nusse, R., Axelrod, J.D. (2008) Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling. Cell 133, 1093-1105. PDF DOI 10.1016/j.cell.2008.04.048
    Supplemental Online Material: ( PDF)

  • Raffard, R., Amonlirdviman, K., Axelrod, J.D. and Tomlin, C. (2008) An Adjoint-based Parameter Identifcation Algorithm applied to Planar Cell Polarity Signaling. Joint Issue of IEEE Transactions on Circuits and Systems and IEEE Transactions on Automatic Control January, 2008, 109-121. PDF

  • Deans, M.R., Antic, D., Suyama, K., Scott, M.P., Axelrod, J.D. and Goodrich, L.V. (2007) Asymmetric distribution of Prickle-Like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Journal of Neuroscience 27, 3139-3147. PDF DOI:10.1523/JNEUROSCI.5151-06.2007

  • Guan, J., Li, H., Rogulja, A., Axelrod, J.D. and Cadigan, K.M. (2007) The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Dev Biol. 303, 16-28. PDF doi:10.1016/j.ydbio.2006.10.028.

  • Raffard, R., Amonlirdviman, K., Axelrod, J. D., and Tomlin, C. J. (2006) Automatic Parameter Identification via the Adjoint Method, with Application to Understanding Planar Cell Polarity. In the Proceedings of the 45th IEEE Conference on Decision and Control, San Diego

  • Kovoor, A., Seyffarth, P., Ebert, J., Barghashoon, S., Chen, C.K., Schwarz, S., Axelrod, J.D., Simon, M.I., Lester, H.A., Schwarz, J. (2005) D2-dopamine receptors colocalize RGS9-2 via the RGS9 DEP domain and RGS9 knockout mice develop dyskinesias associated with dopamine pathways. Journal of Neuroscience 25, 2157-2165. PDF

  • Amonlirdviman, K., Khare, N.A., Tree, D.R.P., Chen, W.-S., Axelrod, J.D. and Tomlin, C.J. (2005) Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science 307, 423-426. PDF
    Supporting Online Material: (19MB high resolution PDF) or (5.3MB low resolution PDF)

  • Ma, D., Yang, C.H., McNeill, H., Simon, M.A. and Axelrod, J.D. (2003) Fidelity in planar cell polarity signalling. Nature 421, 543-547. PDF

  • Yang, C.H., Axelrod, J.D. and Simon, M.A. (2002) Regulation of Frizzled by Fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108, 675-688. PDF

  • Tree, D.R., Shulman, J.M., Rousset, R., Scott, M.P., Gubb, D. and Axelrod, J.D. (2002) Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell 109, 371-381. PDF

  • Winter, C.G., Wang, B., Ballew, A., Royou, A., Karess, R., Axelrod, J.D. and Luo, L. (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105, 81-91. PDF

  • Rousset, R., Mack, J.A., Wharton, K.A., Jr., Axelrod, J.D., Cadigan, K.M., Fish, M.P., Nusse, R. and Scott, M.P. (2001) naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev 15, 658-671. PDF

  • Axelrod, J.D. (2001) Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev 15, 1182-1187. PDF

  • Axelrod, J.D., Miller, J.R., Shulman, J.M., Moon, R.T. and Perrimon, N. (1998) Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev 12, 2610-2622. PDF

  • Rulifson, E.J., Micchelli, C.A., Axelrod, J.D., Perrimon, N. and Blair, S.S. (1996) wingless refines its own expression domain on the Drosophila wing margin. Nature 384, 72-74. PDF

  • Park, M., Wu, X., Golden, K., Axelrod, J.D. and Bodmer, R. (1996) The wingless signaling pathway is directly involved in Drosophila heart development Dev Biol 177, 104-116. PDF

  • Klingensmith, J., Yang, Y., Axelrod, J.D., Beier, D.R., Perrimon, N. and Sussman, D.J. (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev 58, 15-26. PDF

  • Axelrod, J.D., Matsuno, K., Artavanis-Tsakonas, S. and Perrimon, N. (1996) Interaction between Wingless and Notch signaling pathways mediated by Dishevelled. Science 271, 1826-1832. PDF

  • Benjamin, R.J., Linsley, L., Axelrod, J.D., Churchill, W.H., Sieff, C., Shulman, L.N., Elias, A., Ayash, L., Malachowski, M.E., Uhl, L. and et al. (1995) The collection and evaluation of peripheral blood progenitor cells sufficient for repetitive cycles of high-dose chemotherapy support. Transfusion 35, 837-844.

  • Axelrod, J.D., Reagan, M.S. and Majors, J. (1993) GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo. Genes Dev 7, 857-869.

  • Axelrod, J.D., Majors, J. and Brandriss, M.C. (1991) Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo. Mol Cell Biol 11, 564-567.

  • Axelrod, J.D. and Majors, J. (1989) An improved method for photofootprinting yeast genes in vivo using Taq polymerase. Nucleic Acids Res 17, 171-183.

  • Lacey, D.L., Axelrod, J., Chappel, J.C., Kahn, A.J. and Teitelbaum, S.L. (1987) Vitamin D affects proliferation of a murine T helper cell clone. J Immunol 138, 1680-1686.

  • Axelrod, J.D. and Pilch, P.F. (1983) Unique cytochalasin B binding characteristics of the hepatic glucose carrier. Biochemistry 22, 2222-2227.

  • Pilch, P.F., Axelrod, J.D., Colello, J. and M.P. Czech, M.P. (1981) Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation. J Biol Chem 256, 1570-1575.

Reviews, Commentary, Chapters (top)