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We can be found in
CCSR-1240 South
Stanford campus map (PDF) |
page maintained by cbrady@stanford.edu
Welcome to the home of the Attardi Laboratory!
The p53 tumor
suppressor gene plays a crucial role in protecting organisms from developing
cancer. Our research is aimed at dissecting the mechanism of p53 action and the
role of target genes it activates in apoptosis and tumor suppression, using the
mouse as a model system. Our strategy is to use a combination of biochemical, cell
biological, and mouse genetic approaches, starting by generating hypotheses
about p53 using primary mouse embryo fibroblasts (MEFs), and then testing them
using knockout technology in the mouse. An understanding of p53 function in the
mouse will ultimately be useful for understanding how inactivation of p53 in
humans leads to cancer and for designing therapies for the many tumors disrupted
in the p53 pathway. We can be found in
CCSR-1240 South
Stanford
campus map (PDF)
page maintained by cbrady@stanford.edu
Stanford University Medical Center
269 Campus Drive
Stanford, CA 94305-5152
ph 650-723-5261
fax 650-723-7382