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Damian Wheelerdamian.wheeler @ stanford.edu |
Post-Doctoral Fellow BS, McGill University, Montreal, Canada I am interested in the ability of calcium channels to couple to gene expression. Excitation-transcription coupling plays very important roles throughout brain development and in the adult where it mediates long-term adaptive changes associated with processes such as learning and memory and addiction. In my experiments I study the mechanisms by which L-type Ca2+ channels couple to signal transduction pathways that result in the phosphorylation of the transcription factor CREB in the nucleus. Further, I have a keen interest in the mechanisms by which nicotinic acetylcholine receptors respond to nicotine to produce long-term adaptive changes that are associated with tobacco addiction. |
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Selected Publications |
Wheeler DG, Barrett CF, Tsien RW (2007) Multiple mechanisms underlie the privileged role of L-type Ca2+ channel in signaling to the nucleus (in preparation). Wheeler DG*, Barrett CF*, Safa P, Tsien RW (2007) Excitation-transcription coupling in sympathetic neurons. (in preparation). Wheeler DG*, Barrett CF*, Tsien RW (2006) L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors. Neuropharmacology. 51(1):27-36. PubMed Wheeler, D.G. and Cooper, E. (2004) Weak synaptic activity induces ongoing signaling to the nucleus that is enhanced by BDNF and suppressed by low-levels of nicotine. Mol. Cell. Neuro. 26(1):50-62. PubMed Keller, M.J., Wheeler, D.G., Cooper, E. and Meier, J. L. (2003) Role of the human cytomegalovirus major immediate-early promoter's 19-base-pair-repeat cyclic AMP-response element in acutely infected cells. J Virol. 77(12):6666-75. PubMed Wheeler, D.G. and Cooper, E. (2001) Depolarization strongly induces human CMV major immediate-early promoter/enhancer activity in neurons. J. Biol. Chem. 276(34):31978-31985. PubMed Canaff, L., Bevan, S., Wheeler, D.G., Mouland, A.J. Rehfuss, R.P., White, J.H. and Hendy, G.N. (1998) Analysis of the molecular mechanisms controlling neuroendocrine cell specific transcription of the Chromogranin A gene. Endocrinology 139(3):1184-96. Pubmed Wheeler, D.G., Horsford, J., Michalak, M., White, J. and Hendy, G. (1995) Calreticulin inhibits vitamin D3 signal transduction by blocking DNA binding of VDR/RXR heterodimers. Nuc. Acids Res. 23(16):3268-3274. Pubmed
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