We study signaling mechanisms that link electrical activity to cytoplasmic events and to intracellular and intercellular signaling. For example, voltage-gated Ca2+ channels are found in the surface membrane of a wide variety of cells. By rapidly affecting the level of cytoplasmic Ca2+, they exert a strong influence on diverse cellular responses such as neurotransmitter release, electrical activity, motility and gene expression. We try to understand the workings of the Ca2+ channels themselves as well as their modes of communication with the synaptic release machinery and with the cell nucleus.

Stanford University
Beckman Center B101, B103
279 Campus Drive
Stanford, CA 94305