| Cystic Fibrosis Research Laboratory Phone: 650.725.2468 FAX: 650.725.5699 July 4, 2008 Stanford University 
Jordan Hall, Main Quad Stanford, CA, 94305-2130 Mission: CFRL
carries out basic research designed to ameliorate cystic fibrosis lung
disease, which is the major cause of illness and death among CF
patients. Our hypothesis is that CF lungs will retain near normal
function if infections can be held at bay. We further hypothesize
that the susceptibility to lung infections is the result of abnormal
airway mucus, which, because of the failure of CFTR-dependent,
anion-mediated fluid secretion, is deficient in both its ability to
arrest bacterial growth and to sweep bacteria from the airways.
(JJW, 7/4/2008)
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