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Chemistry Faculty :
Faculty Research Interests John A. Flygare
Principal Research Interests
The research in my laboratory is conducted at Genentech in South San Francisco. The goal of our research is to synthesize organic molecules that control biological pathways and lead to novel medicines. Recent work has focused on the role of apoptosis in regulating the cell death of various forms of cancer. Representative Publications
1) "Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists," C. Ndubaku, E. Varfolomeev, L. Wang, K. Zobel, K. Lau, L.O. Elliott, B. Maurer, A.V. Fedorova, J.N. Dynek, M. Koehler, S.G. Hymowitz, V. Tsui, K. Deshayes, W.J. Fairbrother, J.A. Flygare, D. Vucic, ACS Chem. Biol, 4 (7), 557-566 (2009). 2) "Development of Novel Drugs Targeting Inhibitors of Apoptosis," J.A. Flygare, D. Vucic, Future Oncology, 5, 141-144 (2009). 3) "Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold," F. Cohen, B. Alicke, L.O. Elliott, J.A. Flygare, T. Goncharov, S.K. Keteltas, M.C. Franklin, JS. Frankovitz, J.P. Stephan, V. Tsui, D. Vucic, H. Wong, W.J. Fairbrother, J. Med. Chem, 52, 1723-1730 (2009). 4) "Azabicyclo-octane Inhibitors of IAP," F. Cohen, W. Fairbrother, J.A. Flygare, S.F. Keteltas, V.H. Tsui, US 7345081 (2008). 5) "IAP antagonists induce rapid auto-ubiquitination of c IAPs, NF-kB activation, and TNFa-dependent apoptosis," E. Varfolomeev, J.W. Blankenship, S.M. Wayson, A.V. Fedorova, P. Garg, N. Kayagaki, K. Zobel, J. Dynek, L.O. Elliott, H.J.A. Wallweber, J.A. Flygare, W.J. Fairbrother, K. Deshayes, V.M. Dixit, D. Vucic, Cell, 131,, 669-681 (2007). |
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