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Chemistry Faculty :
Faculty Research Interests

>Chemistry Faculty Lecturers	Courtesy Faculty	Emeriti

John A. Flygare

Title: Lecturer (b. 1962)

Education: B.S., 1985, Carleton College; Ph.D., 1990, Northwestern University; N.I.H. Postdoctoral Fellow, Stanford University, 1990-1993; Education, Organic, and Medicinal Chemistry

Course taught: Chemistry 137 (Winter 2010)

Phone: 650-225-6437

E-mail: jflygare@stanford.edu

Courses taught prior to this year: Chemistry 35, 130, 131, 137

Principal Research Interests

The research in my laboratory is conducted at Genentech in South San Francisco. The goal of our research is to synthesize organic molecules that control biological pathways and lead to novel medicines. Recent work has focused on the role of apoptosis in regulating the cell death of various forms of cancer.

Representative Publications

1) "Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists," C. Ndubaku, E. Varfolomeev, L. Wang, K. Zobel, K. Lau, L.O. Elliott, B. Maurer, A.V. Fedorova, J.N. Dynek, M. Koehler, S.G. Hymowitz, V. Tsui, K. Deshayes, W.J. Fairbrother, J.A. Flygare, D. Vucic, ACS Chem. Biol, 4 (7), 557-566 (2009).

2) "Development of Novel Drugs Targeting Inhibitors of Apoptosis," J.A. Flygare, D. Vucic, Future Oncology, 5, 141-144 (2009).

3) "Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold," F. Cohen, B. Alicke, L.O. Elliott, J.A. Flygare, T. Goncharov, S.K. Keteltas, M.C. Franklin, JS. Frankovitz, J.P. Stephan, V. Tsui, D. Vucic, H. Wong, W.J. Fairbrother, J. Med. Chem, 52, 1723-1730 (2009).

4) "Azabicyclo-octane Inhibitors of IAP," F. Cohen, W. Fairbrother, J.A. Flygare, S.F. Keteltas, V.H. Tsui, US 7345081 (2008).

5) "IAP antagonists induce rapid auto-ubiquitination of c IAPs, NF-kB activation, and TNFa-dependent apoptosis," E. Varfolomeev, J.W. Blankenship, S.M. Wayson, A.V. Fedorova, P. Garg, N. Kayagaki, K. Zobel, J. Dynek, L.O. Elliott, H.J.A. Wallweber, J.A. Flygare, W.J. Fairbrother, K. Deshayes, V.M. Dixit, D. Vucic, Cell, 131,, 669-681 (2007).

6) "Inhibitors of IAP," F. Cohen, K. Deshayes, W.J. Fairbrother, B. Feng, J.A. Flygare, L.J. Gazzard, V.H. Tsui, US 7244851 (2007).

7) "Design, Synthesis, and Biological Activity of a Potent Smac Mimetic that Sensitizes Cancer Cells to Apoptosis by Antagonizing IAP Proteins," K. Zobel, L. Wang, E. Varfolomeev, M.C. Franklin, L. Elliott, H.J.A. Wallweber, D.C. Okawa, J.A. Flygare, D. Vucic, W.J. Fairbrother, K. Deshayes, ACS Chem. Biol., 1 (8), 525 (2006).