Stanford University | Chemistry Department | Faculty | Chemistry Faculty

Chemistry Faculty :
Faculty Research Interests

>Chemistry Faculty Lecturers	Courtesy Faculty	Emeriti

John A. Flygare

Title: Lecturer (b. 1962)

Education: B.S., 1985, Carleton College; Ph.D., 1990, Northwestern University; N.I.H. Postdoctoral Fellow, Stanford University, 1990-1993; Education, Organic, and Medicinal Chemistry

Courses Taught: Chemistry 137 (Winter 2007)

Phone: 650-225-6437

E-mail: jflygare@stanford.edu

Courses taught in 2007-2008: Chemistry 137 (Winter 2008)

Principal Research Interests

The research in my laboratory is conducted at Genentech in South San Francisco. The goal of our research is to synthesize organic molecules that control biological pathways and lead to novel medicines. Recent work has focused on the role of apoptosis in regulating the cell death of various forms of cancer.

Representative Publications

1) "IAP antagonists induce rapid auto-ubiquitination of c IAPs, NF-kB activation, and TNFa-dependent apoptosis," Varfolomeev, E.; Blankenship, J.W.; Wayson, S.M.; Fedorova, A.V.; Garg, P.; Kayagaki, N.; Zobel, K.; Dynek, J.; Elliott, L.O.; Wallweber, H.J.A.; Flygare, J.A.; Fairbrother, W.J.; Deshayes, K.; Dixit V.M.; Vucic, D. Cell 2007, 131, 1-13.

2) "Inhibitors of IAP," Cohen, F.; Deshayes, K; Fairbrother, W.J.; Feng, B.; Flygare, J.A.; Gazzard, L.J.; Tsui, V.H. US 7244851 (2007).

3) "Pentafluorobenzenesulfonamides and Analogs," Flygare, J.A.; Medina, J.C.; Shan, B.; Clark, D.L.; Rosen, T.J. US 7138418 (2006).

4) "Design, Synthesis, and Biological Activity of a Potent Smac Mimetic that Sensitizes Cancer Cells to Apoptosis by Antagonizing IAP Proteins," Zobel, K.; Wang, L.; Varfolomeev, E.; Franklin, M.C.; Elliott, L.; Wallweber, H.J.A.; Okawa, D.C.; Flygare, J.A.; Vucic, D.; Fairbrother, W.J.; Deshayes, K. ACS Chemical Biology1, 525 (2006).

5) "Discovery of a Novel Series of Inhibitors of Human Cytomegalovirus Primase," Cushing, T.D.; Adrian, J.; Chen, X.; DiMaio, H.; Doughan, B.; Flygare, J.A.; Liang, L.; Mayorga, V.; Miao, S.; Mellon, H.; Peterson, M.G.; Powers, J.P.; Spector, F.; Stein, C.; Wright, M.; Xu, D.; Ye, Q.; Jaen, J. Bioorg. Med. Chem. Let.16, 4879 (2006).

6) "Serine Protease Inhibitors," Aliagas-Martin, Ignacio; Artis, Dean R.; Dina, Michael S.; Flygare, John A.; Goldsmith, Richard A.; Munroe, Regina A.; Olivero, Alan G.; Pastor, Richard; Rawson, Thomas E.; Robarge, Kirk D.; Sutherlin, Daniel P.; Weese, Kenneth J.; Zhou, Aihe; Zhu, Yan, US 6919369 (2005).

7) "A selective, slow-binding inhibitor of factor VIIa binds to a non-standard active site conformation and attenuates thrombus formation in vivo," Alan G. Olivero, Charles Eigenbrot, Richard Goldsmith, Kirk Robarge, Dean R. Artis, John Flygare, Thomas Rawson, Daniel P. Sutherlin, Saloumeh Kadkhodayan, Maureen Beresini, Linda O. Elliott, Geralyn G. DeGuzman, David W. Banner, Mark Ultsch, Ulla Marzec, Stephen R. Hanson, Canio Refino, Stuart Bunting, and Daniel Kirchhofer J. Biol. Chem., 280, 9160 (2005).

8) "Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)," M. C. Franklin, S. Kadkhodayan, H. Ackerly, D. Alexandru, M.D. Distefano, L.O. Elliott, J.A. Flygare, G. Mausisa, D. C. Okawa, D. Ong, D. Vucic, K. Deshayes, and W.J. Fairbrother Biochemistry, 42, 8223 (2003).