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3rd Annual Merck Symposium
Merck Speaker: About the Lecture: The catalytic mechanisms employed by RNA are chemically more diverse than initially suspected. Divalent metal ions, nucleobases, ribosyl hydroxyl groups, and even functional groups on metabolic cofactors all contribute in the various strategies employed by RNA enzymes. This catalytic breadth raises intriguing evolutionary questions about how RNA lost its biological role in some cases, but not in others, and what catalytic roles RNA might still be playing in biology. About Strobel: Scott Strobel is professor and chair of the Department of Molecular Biophysics and Biochemistry at Yale University where he is a professor of the Howard Hughes Medical Institute. Dr. Strobel received his Ph.D. from Caltech in 1992 under the direction of Professor Peter Dervan. He completed his postdoctoral training in 1995 at the University of Colorado at Boulder under the direction of Professor Thomas Cech. He began his faculty appointment at Yale University in 1995 and was promoted to Professor with tenure in 2001. His work employs organic and structural approaches to understand the chemical basis of RNA catalysis. About the Merck Symposium:
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"RNA Catalysis: Ribozymes, Ribosomes and Riboswitches"