Organic Chemistry Seminar

Wednesday, April 4th
Professor Andrei Yudin
"Amphoteric Molecules for Organic Synthesis"

4:15pm - 5:15pm
Braun Lecture Hall
S.G.Mudd Chemistry Building
Stanford University



This seminar is free and open to the public. All Stanford University Chemistry students are encouraged to attend this special event.

About the Seminar:
Synthetic methods that do not rely on protecting groups are of strategic significance to chemical synthesis. We recently took a view that molecules equipped with reactive functionalities that are kinetically stabilized against inter- or intramolecular reactions with each other could be particularly useful. Along these lines, a new class of stable compounds that contain seemingly incompatible functional groups, namely an aldehyde and an unprotected amine, has been identified. The thermodynamic driving force to undergo condensation between these two functionalities is offset by a high barrier imposed on this process by the aziridine ring strain. These novel amphoteric molecules are stable to epimerization and contain two orthogonal reaction centers. Their ability to act as linchpins has been demonstrated in complex heterocycle synthesis. These and related topics will be discussed.


About Yudin:
In 1992 Yudin received his B.Sc. in Chemistry at the Moscow State University and his Ph.D. in Chemistry University of Southern California with Professors G. K. S. Prakash and G. A. Olah in 1996. He became Postdoctoral Fellow, The Scripps Research Institute with Professor K. Barry Sharpless (1996-1998). Yudin became and Assistant Professor in the Chemistry Department at the University of Toronto in 1998 gaining his Tenure 2002 and Full Professor status in 2007.

Questions:
Please contact Patricia Dwyer at 650-723-4770.