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Chemistry Seminar Program
Inorganic Chemistry Seminar Tuesday, April 17th Professor Katrina Miranda “Design of New Nitroxyl (HNO) Donors with Analytical and Pharmacological Utility”  4:15pm - 5:15pm Braun Lecture Hall S.G.Mudd Chemistry Building Stanford University This seminar is free and open to the public. All Stanford University Chemistry students are encouraged to attend this special event. About the seminar: Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. The responses elicited by HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. The relevance of HNO to endogenous signaling is still a matter of debate, in part due to a poor understanding of its basic chemistry and to limited techniques to define its role in biology. Further, due to rapid self-consumption, HNO must be produced in situ. The most common donor is a nitrogen oxide salt, Na2N2O3 (Angeli’s salt), which has proven to be invaluable in the initiation of the study of the unique chemical properties and pharmacological effects of HNO. However, therapeutic exploitation of HNO will only be possible with development of donors with adaptable backbones to complement those that already exist for NO. The synthesis of a new class of HNO donors with enhanced analytical and pharmacological utility compared to Angeli’s salt will be discussed. About Miranda: Katrina Marie Miranda is an Assistant Professor in the Department of Chemistry at the University of Arizona in Tucson. Miranda received her B.S in chemistry from Northern Arizona University in Flagstaff in 1989. She went on to earn her Ph.D., from the University of California, Santa Barbara in 1996. Miranda has also studied Cell Biology & Physiology at the University of New Mexico in Albuquerque and Radiation Biology at the National Institutes of Health in Bethesda Maryland. Questions: Please contact Patricia Dwyer at 650-723-4770.
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