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Chemistry Seminar Program
Organic Chemistry Seminar
Wednesday, October 24th
Professor
"Phosphine Catalysis of Allenes in Target-Oriented Synthesis
(TOS) and Diversity-Oriented Synthesis (DOS)
"
4:15pm - 5:15pm
Braun Lecture Hall
S.G.Mudd Chemistry Building
Stanford University
This seminar is free and open to the public. All Stanford University Chemistry students are encouraged to attend this special event.
About the seminar:
Our group research interest lies in the area of development
of new organic reactions, target oriented synthesis (TOS) of biologically
important natural products, and diversity oriented synthesis (DOS) of
natural product and drug-like molecules. The seminar will present recent
progress made in each area. Specifically, I will talk about the development
of new phosphine-catalyzed reactions using allenes, chiral phosphine design
for enantioselective processes, application of the phosphine catalysis to
the total synthesis of bioactive indole alkaloids, and diversity-oriented
combinatorial synthesis of libraries of small organic molecules and their
applications in chemical genetics. Some recent publications that highlight
our group research progress are the following:
About Kwon:
Ohyun Kwon received her B.S. (1991) and M.S. (1993) from
Seoul National University in South Korea. In 1993, she came to the U.S. to
pursue her Ph.D. (1998) from Columbia University under the guidance of S. J.
Danishefsky. [Her thesis work involved the synthesis of biologically
significant glycolipids, asialo GM1 and Globo-H human breast tumor antigen
molecules, as well as complex phomoidrid terpenoids, CP-225,917 and
CP-263,114.] She then went to Harvard University as a Howard Hughes
Postdoctoral Fellow to study chemical genetics in S. L. Schreiber's lab.
[There, she completed a diversity-oriented combinatorial synthesis (DOS) of
a library of muticyclic compounds, as well as a library of macrocycles.]
Kwon joined the faculty as an assistant professor at UCLA in 2001. She has
built a strong research program at UCLA that evolves around the nucleophilic
phosphine catalysis. [She was one of the first recipients of the Amgen Young
Investigator's Award in 2003 and was also the 2005 Thieme Journal Awardee.
She has given over 50 invited lectures at international conferences,
universities, pharmaceutical companies and biotech companies. Her current
research group consists of four post-doctorates, eight graduate students,
one research assistant, and two undergraduate students.]
Questions
Please contact Patricia Dwyer at 650-723-4770.
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