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Conferences & Lectures :
W.S. Johnson Speaker:24th Annual William S. Johnson Symposium Michael J. Krische  University of Texas About Krische: Professor Michael J. Krische obtained a B.S. degree in Chemistry from the University of California at Berkeley, where he performed research with Professor Henry Rapoport. After one year of study abroad as a Fulbright Fellow, he initiated graduate research at Stanford University with Professor Barry Trost as a Veatch Graduate Fellow. Following receipt of his Ph.D. degree, he worked with Jean-Marie Lehn at the Université Louis Pasteur as an NIH Post-Doctoral Fellow. In Fall 1999, Professor Krische was appointed Assistant Professor at the University of Texas at Austin. He was promoted directly to Full Professor in Fall 2004 and in Fall 2007 was appointed the Robert A. Welch Chair in Science. Krische's lecture at the Johnson Symposium: "Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation " Alkene hydroformylation is the largest volume application of homogenous metal catalysis and may be viewed as the prototypical C-C bond forming hydrogenation. Despite the impact of hydroformylation, systematic efforts to generalize this process are absent. Using carefully tailored hydrogenation catalysts, the Krische group has found that diverse ?-unsaturated reactants reductively couple to carbonyl compounds and imines under hydrogenation conditions, offering a byproduct-free alternative to stoichiometric organometallics in a range of classical C=X (X = O, NR) addition processes. This concept is extended further via C-C bond forming transfer hydrogenation - reactions in which an alcohol serves dually as hydrogen donor and precursor to the carbonyl electrophile, enabling carbonyl addition from the alcohol oxidation level in the absence of stoichiometric organometallic reagents.  Selected Publications Review: “Catalytic Carbonyl Addition through Transfer Hydrogenation: A Departure from Preformed Organometallic Reagents,” Bower, J. F.; Kim, I. S.; Patman, R. L.; Krische, M. J. Angew. Chem. Int. Ed. 2009, 48, 34. “Direct Vinylation of Alcohols or Aldehydes Employing Alkynes as Vinyl Donors: A Ruthenium Catalyzed C-C Bond Forming Transfer Hydrogenation,” Patman, R. L.; Chaulagain, M. R.; Williams, V. M.; Krische, M. J. J. Am. Chem. Soc. 2009, 131, 2066. “Enantioselective Iridium Catalyzed Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level Using Allyl Acetate as an Allyl Metal Surrogate,” Kim, I. S.; Ngai, M.-Y.; Krische, M. J. J. Am. Chem. Soc. 2008, 130, 6340. “Enantioselective Iridium Catalyzed Imine Vinylation: Optically Enriched Allylic Amines via Alkyne-Imine Reductive Coupling Mediated by Hydrogen,” Barchuk, A.; Ngai, M.-Y.; Krische, M. J. J. Am. Chem. Soc. 2007, 129, 12644. “Diastereo- and Enantioselective Hydrogenative Aldol Coupling of Vinyl Ketones: Design of Effective Monodentate TADDOL-Like Phosphonite Ligands,” Bee, C.; Han, S. B.; Hassan, A.; Iida, H.; Krische, M. J. J. Am. Chem. Soc. 2008, 130, 2747. Questions: If you have questions or need additional information please contact Patricia Dwyer at 650-723-4770 |
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