Radiation Safety Manual 1997

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I-125
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I-125

RADIONUCLIDE SAFETY DATA SHEET

NUCLIDE: I-125 FORMS: INORGANIC OR FREE IODINE
PHYSICAL CHARACTERISTICS:
HALF LIFE: 60 days TYPE DECAY: e- capture
Gamma rays: 0.035 MeV (7%)
X-rays: 0.027 – 0.031 MeV (140%)
Hazard Category: C - level (low hazard): 0.1 to 200 m Ci
B - level (moderate hazard): >200 m Ci to 10 mCi
A – level (high hazard): greater than 10 mCi

EXTERNAL RADIATION HAZARDS AND SHIELDING:

      The exposure rate at 1 cm from a 1 mCi is 1.5 R/hr. (Exposure varies directly with activity and inversely with the square of the distance from the materials.)

      Amount of lead required to reduce the exposure rate by a factor of 10 (1 TVL) is approximately 0.1 mm. 1/8 inch of glass would reduce the exposure rate by half. Leaded rubber gloves (0.1 mm lead = 1 TVL) are available from Health Physics.

HAZARDS IF INTERNALLY DEPOSITED:

      Contamination on the skin or inhalation from air containing iodine vapors will result in internal deposition. Iodide solutions are easily oxidized and the elemental iodine will become airborne. About 70% of activity inhaled is deposited in the body and about 30% of that is deposited in the thyroid. Ingestion of 4 m Ci, or inhalation of 6 m Ci, would result in that glad’s receiving Stanford’s ALARA guideline, i.e., 5 rem.

      Blocking the uptake of radioiodine with the stable nuclide is not permitted. WORK IN PROPER FUME HOODS. (See Radiation Safety Manual, Part III).

DOSIMETRY AND BIOASSAY REQUIREMENTS:

      Film badges and dosimeter rings are usually required if 5 millicuries are handled at any one time or if millicurie levels are handled on a frequent (daily) basis.

      Arrange for a thyroid survey within 24-48 hours after the first procedure; thereafter, every three months.

SPECIAL PROBLEMS AND PRECAUTIONS:

  1. GM survey meters have a poor efficiency of detection for I125. Survey by smear tests or use Nal (TI) Scintillation probes.
  2. Segregate wastes to those with half-lives from 19 days to less than 65 days. Assume items in work areas are contaminated unless cleared with a Nal scintillation survey meter. Wrap all waste items in plastic bags prior to placing them in waste.
  3. Limit of soluble wastes to the sewer is 100 m Ci / month per lab.
  4. Wear double gloves. Change gloves often.
  5. See separate Radiation Safety Data Sheet for non-volatile or non-cleaving compounds.

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