Use of Human Subjects in Research  

Course Introduction  
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Background    

The formal codification of ethical guidelines for the conduct of research involving humans began in the late 1940's.

In 1946, 23 Nazi physicians went on trial at Nuremberg because of research atrocities performed on prisoners of war.

Subsequently, in 1947, the Nazi War Crimes Tribunal issued the Nuremberg Code, which was the first internationally recognized code of research ethics.

While the Nuremberg Code and subsequent ethical guidelines represented the most enlightened thinking of the time, many well-intentioned researchers did not know about them or did not apply this guidance to their research activities.

 

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