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History
Timeline of Discovery
of F. hepatica
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De Brie, 1379 |
First observation of cercariae in snail |
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Swammerdam, 1737 |
First observation of F. hepatica |
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Muller, 1773 |
Cercariae were seen in water |
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Zeder, 1803 |
Life cycle was described including the hatching of egg |
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Nitzsch, 1807 |
The encysting of cercariae was studied |
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Steenstrup, 1842 |
Elucidated the idea of an alternating generation in
parasite development |
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Weinland, 1875 |
L. truncatula was determined as the intermediate host
for the larval stage of the liver fluke |
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Leuckart 1882 |
First to describe the life cycle of F. hepatica and
confirm its host |
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Lutz, 1892 |
Elucidated the mode of transmission of the parasites to
herbivores |
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Sinitsin, 1914 |
etermined the route of transmission to humans and D
organ damage caused by the parasite.
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Source:
Andrews, SJ. The Life Cycle
of Fasciola hepatica. CAB
International, 1999. <http://www.cabipublishing.org/pdf/Books/0851992609/2609ch1.pdf> |
Discovery of Fasciola gigantica
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In the 1875 issue of the
Lancet J.F.P McConnell, a
physician and pathologist in
Calcutta, described the
morphology, anatomy, and
pathogenesis of a new live
fluke which he was able to
isolate from an infected
Chinese man.
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McConnell’s
Illustration of the F. gigantica Anatomy
Source: McConnell, JFP. Anatomy and
Pathological Relations of a New Species of
Liver-fluke. The Lancet 1875 Aug:
271.
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Description of the
New Liver Fluke |
Source:
McConnell, JFP. Anatomy and Pathological
Relations of a New Species of Liver-fluke.
The Lancet 1875 Aug: 271.
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