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Treatment involves surgery for lesion if accessible. There are also two
categories of drugs, Antihelminthic agents and
Glucocorticoids, that may be used for T.multiceps, as well as all
other Taeniid infections. Chemotherapy treatment is not available.
Drug Category: Antihelminthic agents- Praziquantel is considered
the drug
of choice. Niclosamide also can be used. Both are administered as a
single-dose therapy.
Drug Name:Praziquantel- The drug of choice for Taeniid infections.
Increases cell membrane permeability in susceptible worms, resulting in
loss of intracellular calcium, massive contractions, and paralysis of
musculature.
Adult Dose:5-10 mg/kg
Precautions:Mild and transient adverse effects include
dizziness, headache, abdominal pain, fatigue, malaise, and limb pain.
Drug NameNiclosamide- Acts by causing necrosis of the
head and adjoining segments of the tapeworm. The worm loses its hold and
is eliminated in pieces or intact with the feces.
Adult Dose:Available as 500-mg tab.
Precautions:Most adverse effects are mild and transient including
vomiting, nausea, and abdominal distress.
Drug Name:Albendazole- Decreases ATP production in worm,
causing energy depletion, immobilization, finally death.
Adult Dose:15 mg/kg
Precautions:Abdominal pain, nausea, vomiting, diarrhea,
dizziness, vertigo, fever, increased intracranial pressure,
and alopecia may occur.
Drug Category: Glucocorticoids-Useful in cases of increased
intracranial
pressure resulting from antihelminthic-induced cyst death and resultant
inflammation.
Drug Name:Dexamethasone-An adrenocortical
steroid.
Decreases inflammation by suppressing migration of polymorphonuclear
leukocytes and reducing capillary permeability.
Adult Dose:1-2 mg/kg initially; followed by 1-1.5 mg/kg for
2-3 days.
Precautions:Increases risk of multiple complications,
including severe
infections.