Mebendazole and albendazole are the antihelmintic agents most commonly prescribed to cure infection.*
These medications immobilize and eventually kill the parasite by impairing
glucose uptake by the larval and adult stages. By binding to the
colchicine-sensitive site of tubulin, these medications prevent polymerization
or assembly of tubulin subunits into microtubules. Thus immobilized,
the parasites exhaust their protective glycogen stores in response to insufficient
energy production and eventually starve to death.
Public health experts focus on the parasite's life cycle and mode of transmission, including reservoirs and hosts, when developing prevention strategies for inhabitants of endemic areas.
Based on this knowledge, inhabitants of endemic areas are advised as follows:
*These drugs are approved by the FDA, but considered investigational for this purpose.
introduction biological agent history & epidemiology life cycle & transmission clinical presentation diagnosis